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Base","Card Contact Full",[1602],{"id":86,"groupTitle":16,"sessions":1603},[1604,1656,1697,1751,1790,1839,1883,1917,1963,2013,2062,2116,2164,2217,2269,2310,2360,2412,2463,2511,2551,2595,2646,2684,2718,2768,2818,2866,2914,2964,2994,3046,3098,3147,3184,3232,3266,3301],{"id":382,"session":1605},{"id":382,"title":1606,"teaser":1607,"body":1608,"createdAt":1609,"updatedAt":1610,"publishedAt":1611,"url_path_id":1612,"contacts":1613,"url_path":1655},"Optimization of Two-Dimensional Liquid Chromatography in Proteomic Analysis","\u003Cp style=\"text-align:justify;\">When conventional high-performance liquid chromatography (HPLC) fails to provide sufficient separation efficiency, two-dimensional liquid chromatography (2D-LC) offers a powerful alternative by substantially increasing peak capacity. Coupled with mass spectrometry, multidimensional separation techniques are particularly well-suited for analyzing highly complex proteomic samples. Despite their advantages, 2D-LC methods are notoriously difficult and timeconsuming to optimize. \u003C/p>","\u003Cp style=\"text-align:justify;\">This work presents the development of a computational optimization model implemented in the Python programming language, addressing key steps in the development of the 2D-LC method. The optimization workflow is based on scouting gradient experiments performed in reversedphase chromatography and hydrophilic interaction liquid chromatography. Using retention modeling, the program predicts analyte behavior across the two-dimensional separation space and provides visualization of the resulting chromatograms. Additionally, the model optimizes column dimensions, allowing for a systematic evaluation of column length and internal diameter to maximize the achievable peak capacity.\u003Cbr>\u003Cbr>We found that a longer and narrower column is suitable for the first dimension, whereas a shorter and wider column is more appropriate for the second dimension. The dimensions of the firstdimension column have a smaller impact on the two-dimensional separation capacity than the dimensions of the second-dimension column. The first-dimension column can therefore be considered fractionating, while the second-dimension column can be regarded as separating, which must be taken into account when selecting suitable columns for two-dimensional chromatography. It should be noted, however, that this conclusion applies primarily to the combination of hydrophilic interaction chromatography in the first dimension and reversed-phase chromatography in the second dimension.\u003C/p>","2026-01-12T20:31:04.734Z","2026-01-12T20:31:07.008Z","2026-01-12T20:31:06.997Z","104",[1614],{"id":896,"name":1615,"committee":16,"position":16,"affiliation":1616,"email":16,"biography":1617,"createdAt":1618,"updatedAt":1619,"url_path_id":1620,"contactPhoto":1621,"socialLinks":1653,"url_path":1654}," Jiří Urban","Masaryk University, Brno, Czech Republic","\u003Cp style=\"text-align:justify;\">Jiri Urban received his Ph.D. in 2007 under the supervision of Pavel Jandera at the University of Pardubice, Czech Republic, where he remained until 2016. From 2009 to 2011, he conducted postdoctoral research at the University of California, Berkeley, USA, in the groups of Frantisek Svec and Jean M. J. Fréchet. In 2017, he joined the Department of Chemistry at Masaryk University in Brno, Czech Republic, where he was appointed Associate Professor in 2018 and subsequently became a Full Professor in 2025. His research focuses on the use of multifunctional polymer monoliths for developing new analytical methods applicable to metabolomics and proteomics. He also investigates retention modeling in chromatographic method development and the design of novel instrumental setups for two-dimensional liquid chromatography.\u003C/p>","2026-01-12T20:27:46.222Z","2026-01-13T18:47:50.956Z","103",{"id":1371,"name":1622,"alternativeText":16,"caption":16,"width":1623,"height":1624,"formats":1625,"hash":1649,"ext":1294,"mime":1297,"size":1650,"url":1651,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":1652,"updatedAt":1652},"Jiri-Urban.jpg",2738,1825,{"large":1626,"small":1632,"medium":1638,"thumbnail":1643},{"ext":1294,"url":1627,"hash":1628,"mime":1297,"name":1629,"path":16,"size":1630,"width":41,"height":1631},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Jiri_Urban_99ed57a245.jpg","large_Jiri_Urban_99ed57a245","large_Jiri-Urban.jpg",78.41,667,{"ext":1294,"url":1633,"hash":1634,"mime":1297,"name":1635,"path":16,"size":1636,"width":48,"height":1637},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Jiri_Urban_99ed57a245.jpg","small_Jiri_Urban_99ed57a245","small_Jiri-Urban.jpg",24.72,333,{"ext":1294,"url":1639,"hash":1640,"mime":1297,"name":1641,"path":16,"size":1642,"width":55,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Jiri_Urban_99ed57a245.jpg","medium_Jiri_Urban_99ed57a245","medium_Jiri-Urban.jpg",48.94,{"ext":1294,"url":1644,"hash":1645,"mime":1297,"name":1646,"path":16,"size":1647,"width":1648,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Jiri_Urban_99ed57a245.jpg","thumbnail_Jiri_Urban_99ed57a245","thumbnail_Jiri-Urban.jpg",7.23,234,"Jiri_Urban_99ed57a245",522.48,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Jiri_Urban_99ed57a245.jpg","2026-01-12T20:26:45.868Z",[],"-73","-74",{"id":193,"session":1657},{"id":193,"title":1658,"teaser":1659,"body":1660,"createdAt":1661,"updatedAt":1662,"publishedAt":1663,"url_path_id":1664,"contacts":1665,"url_path":1696},"Particle size distribution and column technologies Does it matter?","\u003Cp style=\"text-align:justify;\">The interplay between column performance, particularly separation speed and resolution, and the macrostructure of randomly packed beds of spherical particles has been a defining theme in chromatography research since the pioneering work of Horvath, Giddings, and Knox in the 1960s. The pursuit of faster, higher-resolution separations has inspired successive innovations: elevated operating temperatures, more ordered packing architectures (e.g., Regnier’s and Desmet’s pillar array columns), reduced flow resistance through highly porous monoliths (Tanaka, Svec), and the leap from conventional HPLC (400 bar) to UHPLC (1000–1500 bar) with sub-2 μm particles at extreme pressures (Jorgenson; Waters Corporation, 2004).\u003C/p>","\u003Cp style=\"text-align:justify;\">Yet, despite remarkable advances in particle technologies, including sub-3 μm core-shell particles with narrow particle size distributions (PSDs) (Kirkland, Advanced Material Technologies, 2007) and the emergence of quasi-monodisperse materials, the precise role of PSD in shaping the speed–resolution trade-off of modern LC columns remains unsettled. The debate persists, often fueled more by conjecture from very limited data than by rigorous systematic, experimental and fundamental validations (See Figure 1). In this presentation, we revisit pivotal simulation and experimental studies to clarify the intrinsic influence of PSD on column permeability and efficiency. We will further identify the critical physico-chemical parameters that must be considered to approach the ultimate performance limits of randomly packed LC columns composed of spheroidal particles.\u003C/p>","2026-01-12T21:49:03.514Z","2026-02-06T16:24:44.540Z","2026-01-12T21:49:04.946Z","107",[1666],{"id":1465,"name":1667,"committee":16,"position":16,"affiliation":1668,"email":16,"biography":1669,"createdAt":1670,"updatedAt":1670,"url_path_id":1671,"contactPhoto":1672,"socialLinks":1694,"url_path":1695},"Fabrice Gritti","Waters Corporation","\u003Cp style=\"text-align:justify;\">Dr. Fabrice G. Gritti earned his Ph.D. in Chemistry and Physics of Condensed Matter from the University of Bordeaux I in 2001. He then worked as a research scientist with Professor Georges Guiochon at the University of Tennessee, a collaboration that lasted until 2014. In 2015, he joined Waters Corporation as a consultant scientist, where he continues to contribute his expertise to advancing chromatographic separation science.\u003C/p>\u003Cp style=\"text-align:justify;\">Dr. Gritti’s research focuses on solid-to-liquid adsorption thermodynamics and mass transfer in chromatographic porous media. His overarching goal is to deepen the understanding of separation and mass transfer mechanisms in existing liquid chromatography (LC) techniques, while driving the development of new column and system technologies that are firmly grounded in scientific principles and responsive to societal needs.\u003C/p>\u003Cp style=\"text-align:justify;\">Throughout his career, Dr. Gritti has authored more than 300 peer-reviewed publications, delivered over 95 keynote lectures, and presented more than 30 seminars worldwide on the advancement of chromatographic sciences. His contributions have been recognized with numerous awards, including:\u003C/p>\u003Cul>\u003Cli style=\"text-align:justify;\">The Chromatographic Society Jubilee Medal (2013)\u003C/li>\u003Cli style=\"text-align:justify;\">The JFK Huber Lecture Award (2019)\u003C/li>\u003Cli style=\"text-align:justify;\">The Eastern Analytical Symposium Award for Outstanding Achievements in Separation Science (2022)\u003C/li>\u003Cli style=\"text-align:justify;\">The Csaba Horvath Memorial Award (2023)\u003C/li>\u003Cli style=\"text-align:justify;\">The A.J.P. Martin Medal (2024)\u003C/li>\u003C/ul>\u003Cp style=\"text-align:justify;\">Dr. Gritti’s work continues to shape the future of separation science, bridging fundamental research with practical innovation to deliver technologies that serve both the academic and industry communities at large.\u003C/p>","2026-01-12T21:48:27.683Z","106",{"id":1673,"name":1674,"alternativeText":16,"caption":16,"width":1675,"height":1676,"formats":1677,"hash":1690,"ext":1294,"mime":1297,"size":1691,"url":1692,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":1693,"updatedAt":1693},114,"Picture1.jpg",542,648,{"small":1678,"thumbnail":1684},{"ext":1294,"url":1679,"hash":1680,"mime":1297,"name":1681,"path":16,"size":1682,"width":1683,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Picture1_4bfd0a2046.jpg","small_Picture1_4bfd0a2046","small_Picture1.jpg",24.1,418,{"ext":1294,"url":1685,"hash":1686,"mime":1297,"name":1687,"path":16,"size":1688,"width":1689,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Picture1_4bfd0a2046.jpg","thumbnail_Picture1_4bfd0a2046","thumbnail_Picture1.jpg",4.11,130,"Picture1_4bfd0a2046",36.36,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Picture1_4bfd0a2046.jpg","2026-01-12T21:47:56.640Z",[],"-75","-76",{"id":257,"session":1698},{"id":257,"title":1699,"teaser":1700,"body":1701,"createdAt":1702,"updatedAt":1703,"publishedAt":1704,"url_path_id":1705,"contacts":1706,"url_path":1750},"Isomer Selectivity in Metabolomics/Lipidomics and Impact in Biomedical Research","\u003Cp style=\"text-align:justify;\">Lipidomics and metabolomics are analytical approaches widely adopted in biomedical research with the aim to obtain mechanistic insights in biochemical processes, to find diagnostic and prognostic biomarkers, and generate new hypothesis about biological processes or validate concepts from other experimentation. Although common untargeted methodologies allow simultaneous analysis of hundreds of metabolites, they often fall short in full coverage of pathways in which isomeric species play a major role, e.g. in oxylipidomics, the phosphoinositide network, glycolysis and pentosephosphate pathways. \u003C/p>","\u003Cp style=\"text-align:justify;\">Nowadays, multiple tools have become available which can support the confident structural annotations of isomeric metabolites such as dataindependent acquisition mass spectrometry, ion-mobility mass spectrometry, multimodal fragmentation with electron-activated dissociation complementing collisional induceddissociation, and double-bond derivatization. Additionally, chiral chromatography may be beneficial for constitutional isomers and is required for enantiomer separations. This presentation will focus on challenging lipid and metabolite classes in targeted and untargeted lipidomics and metabolomics, respectively, for which biological interpretations rely on a separation of their structural isomers.\u003C/p>\u003Cp style=\"text-align:justify;\">In the first part, the structural complexity of the oxylipidome with its numerous isomers will be elucidated. For untargeted analysis the structural annotation of the oxidized lipids requires a powerful library with isomer-characteristic fragments. Standards are only available for a few selected oxidized lipids. Hence, spectra must be generated in silico. This presentation will show the power of data-independent SWATH acquisition in combination with in silico libraries for the structural annotation of the oxylipidome in untargeted analysis of clinical samples such as from platelets of coronary artery disease patients where oxidative stress is observed.\u003C/p>\u003Cp style=\"text-align:justify;\">In the second part, the focus will be on the phosphoinositide pathway. Phosphoinositides are regulating key metabolic processes including signal transduction. Arising from dynamic phosphorylation/dephosphorylation on the inositol ring of phosphatidylinositols (PI), phosphoinositides (PIPx) comprise seven classes according to phosphate position and number. Combined with various fatty acid side chains high structural complexity arises. For a comprehensive understanding of the phosphoinositide signaling, analytical coverage of the entire metabolic network is necessary. Here, we describe an integrated workflow for these metabolites using a single sample aliquot. The application of PIPs profiling to clinical platelet samples will be shown.\u003C/p>\u003Cp style=\"text-align:justify;\">In the third part, the challenges of an integrated workflow covering the entire glycolysis and pentosephosphate pathways with their numerous phosphorylated carbohydrate structural isomers will be discussed. In spite of new HILIC columns with deactivated hardware surface, HILIC separations of the entire sugar phosphate isomer sets remained troublesome. All metabolites of the glycolysis and pentose phosphate pathway are covered with good peak shapes and isomer selectivity and a simple solution to the reported repeatability problem of HILIC will be presented.\u003C/p>","2026-01-12T21:53:53.745Z","2026-02-06T16:54:28.146Z","2026-01-12T21:53:55.362Z","108",[1707],{"id":206,"name":1708,"committee":16,"position":16,"affiliation":1709,"email":16,"biography":1710,"createdAt":1711,"updatedAt":1712,"url_path_id":1713,"contactPhoto":1714,"socialLinks":1748,"url_path":1749},"Michael Lämmerhofer","The University of Tübingen, Germany","\u003Cp style=\"text-align:justify;\">\u003Cspan style=\"font-size:1.125rem;\">Michael Lämmerhofer is Full Professor for Pharmaceutical (Bio-)Analysis at the University of Tübingen, Germany (since 2011). He graduated in Pharmaceutical Sciences in 1992 and earned his PhD in Pharmaceutical Chemistry in 1996 at the University of Graz, Austria (supervisor Prof. Wolfgang Lindner). Between 1997 and 2002 he was assistant professor and from 2002 to 2011 associate professor at the University of Vienna, Institute of Analytical Chemistry. Between 1999-2000 he spent a year as post-doctoral researcher at the Department of Chemistry of the University of California, Berkeley (Prof. Frantisek Svec/Prof. Jean M. Fréchet). Since 2007, he has been associate editor of Journal of Separation Science and since 2024 he is editor-in-chief.\u003C/span>\u003C/p>\u003Cp style=\"text-align:justify;\">\u003Cspan style=\"font-size:1.125rem;\">His research interests include bioanalysis (metabolomics and lipidomics), pharmaceutical analysis (impurity profiling, enantioselective analytics), multidimensional separations and biopharmaceuticals analysis (peptides, oligonucleotides, proteins, plasmids), and the development of functionalized separation materials (chiral stationary phases, mixed-mode phases, chemo- & bioaffinity materials, nanoparticles, monoliths). \u003C/span>\u003Cbr> \u003C/p>","2025-11-07T17:24:53.713Z","2026-01-12T21:53:11.475Z","61",{"id":1715,"name":1716,"alternativeText":16,"caption":16,"width":1717,"height":1718,"formats":1719,"hash":1744,"ext":1721,"mime":1297,"size":1745,"url":1746,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":1747,"updatedAt":1747},85,"Portrait Laemmerhofer.jpg.jpeg",7088,8540,{"large":1720,"small":1727,"medium":1733,"thumbnail":1739},{"ext":1721,"url":1722,"hash":1723,"mime":1297,"name":1724,"path":16,"size":1725,"width":1726,"height":41},".jpeg","https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Portrait_Laemmerhofer_jpg_bf9d795322.jpeg","large_Portrait_Laemmerhofer_jpg_bf9d795322","large_Portrait Laemmerhofer.jpg.jpeg",85.83,830,{"ext":1721,"url":1728,"hash":1729,"mime":1297,"name":1730,"path":16,"size":1731,"width":1732,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Portrait_Laemmerhofer_jpg_bf9d795322.jpeg","small_Portrait_Laemmerhofer_jpg_bf9d795322","small_Portrait Laemmerhofer.jpg.jpeg",25.16,415,{"ext":1721,"url":1734,"hash":1735,"mime":1297,"name":1736,"path":16,"size":1737,"width":1738,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Portrait_Laemmerhofer_jpg_bf9d795322.jpeg","medium_Portrait_Laemmerhofer_jpg_bf9d795322","medium_Portrait Laemmerhofer.jpg.jpeg",50.76,623,{"ext":1721,"url":1740,"hash":1741,"mime":1297,"name":1742,"path":16,"size":1743,"width":1689,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Portrait_Laemmerhofer_jpg_bf9d795322.jpeg","thumbnail_Portrait_Laemmerhofer_jpg_bf9d795322","thumbnail_Portrait Laemmerhofer.jpg.jpeg",4.1,"Portrait_Laemmerhofer_jpg_bf9d795322",2277.59,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Portrait_Laemmerhofer_jpg_bf9d795322.jpeg","2025-11-07T18:51:20.787Z",[],"-34","-77",{"id":219,"session":1752},{"id":219,"title":1753,"teaser":1754,"body":1755,"createdAt":1756,"updatedAt":1757,"publishedAt":1758,"url_path_id":1759,"contacts":1760,"url_path":1789},"Morphological Particle Optimization: A Theoretical Study of the Speed Potential of Spiky Particles in Chromatography","\u003Cp style=\"text-align:justify;\">We report on a computational study to gain insight in the potential advantage of spiky particles in packed bed columns for liquid chromatography. Using the recently adopted Two-Zone Moment Analysis method, a comprehensive set of band broadening data has been generated over an exhaustive range of particle/spike combinations and shapes, velocities, diƯusion coeƯicients and retention factors.\u003C/p>","\u003Cp style=\"text-align:justify;\">It has been found that, compared to the no-spike case, the presence of the spikes can be expected to lead to a drastic decrease of the beds’ flow resistance (up to a factor of 10 and more), as a direct consequence of the increase in external porosity ε caused by the fact that the spikes keep the particles further away from each other. The decrease in flow resistance largely follows the -dependency of the well-established Kozeny-Carman law. The presence of the spikes on the other hand leads to an increased band broadening, but this increase is much more modest than the decrease in flow resistance, such that the overall separation impedance of the spiky particles is still better. This leads to the overall situation that spiky particles, if they can be produced with suƯicient mechanical strength and size uniformity, can be expected to have a much lower minimal separation impedance Emin than their no-spike counterparts. Compared to the no-spike case, the Emin could drop with a factor 3to 4 when Lspike/dp=0.18 (=0.4) and even with a factor 4 to 8 when Lspike/dp=0.25 (=0.5) and 4 to 12 times when Lspike/dp=0.4 (=0.6). However, to truly benefit from this low separation impedance in the plate number range of main practical interest, the addition of the spikes would have to be accompanied by a significant decrease of the particle main body diameter, bringing it at, and even well below, the 1 micrometer mark.\u003C/p>","2026-01-12T22:21:31.167Z","2026-02-06T21:05:22.557Z","2026-01-12T22:21:32.700Z","109",[1761],{"id":182,"name":1762,"committee":16,"position":16,"affiliation":1763,"email":16,"biography":1764,"createdAt":1765,"updatedAt":1766,"url_path_id":1767,"contactPhoto":1768,"socialLinks":1787,"url_path":1788},"Gert Desmet","Vrije Universiteit Brussel (VUB), Brussels, Belgium","\u003Cp style=\"text-align:justify;\">Gert Desmet has a PhD in chemical engineering from the Vrije Universiteit Brussel (VUB), Brussels, Belgium, where he currently is a full professor. His research focuses on the miniaturization and automation of separation methods, as well as on the investigation and the modeling of flow effects in chromatographic systems. He has been the author or co-author of more than 450 peer-reviewed papers. He currently is the Deputy-director of the Solvay Institute for Chemistry, is an Associate Editor for Analytical Chemistry\" and was the recipient of an ERC Advanced Grant. He is also a member of the permanent scientific committees of the international HPLC and ISC conference series. \u003C/p>","2025-06-03T15:40:50.894Z","2026-01-12T22:20:52.110Z","29",{"id":1769,"name":1770,"alternativeText":16,"caption":16,"width":1771,"height":1771,"formats":1772,"hash":1783,"ext":1294,"mime":1297,"size":1784,"url":1785,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":1786,"updatedAt":1786},52,"Gert Desmet_cropped.jpg",720,{"small":1773,"thumbnail":1778},{"ext":1294,"url":1774,"hash":1775,"mime":1297,"name":1776,"path":16,"size":1777,"width":48,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Gert_Desmet_cropped_8b984d34dc.jpg","small_Gert_Desmet_cropped_8b984d34dc","small_Gert Desmet_cropped.jpg",70.37,{"ext":1294,"url":1779,"hash":1780,"mime":1297,"name":1781,"path":16,"size":1782,"width":937,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Gert_Desmet_cropped_8b984d34dc.jpg","thumbnail_Gert_Desmet_cropped_8b984d34dc","thumbnail_Gert Desmet_cropped.jpg",5.32,"Gert_Desmet_cropped_8b984d34dc",138.85,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Gert_Desmet_cropped_8b984d34dc.jpg","2025-07-11T22:06:47.089Z",[],"-4","-78",{"id":251,"session":1791},{"id":251,"title":1792,"teaser":1793,"body":1794,"createdAt":1795,"updatedAt":1796,"publishedAt":1797,"url_path_id":1798,"contacts":1799,"url_path":1838},"The in vivo 3D Proteome","\u003Cp style=\"text-align:justify;\">Numerous studies have investigated changes in protein expression at the system level using proteomic mass spectrometry, but only recently have studies explored the structure of proteins at the proteome level. We developed covalent protein painting (CPP), a protein footprinting method that quantitatively labels exposed lysine, and have now extended the method to whole intact animals to measure surface accessibility as a surrogate of in vivo protein conformations. These types of methods will allow the interrogation of the in vivo 3-Dimensional proteome to study different aspects of biology and disease.\u003C/p>","\u003Cp style=\"text-align:justify;\">We investigated how protein structure and protein expression change as Alzheimer's disease (AD) progresses by conducting in vivo whole animal labeling of AD mice. This allowed us to analyze broadly protein accessibility in various organs over the course of AD. We observed that structural changes of proteins related to 'energy generation,' 'carbon metabolism,' and 'metal ion homeostasis' preceded expression changes in the brain. We found that proteins in certain pathways undergoing structural changes were significantly co-regulated in the brain, kidney, muscle, and spleen.\u003C/p>","2026-01-12T22:27:15.750Z","2026-03-18T22:41:22.363Z","2026-01-12T22:27:17.056Z","110",[1800],{"id":144,"name":1801,"committee":16,"position":16,"affiliation":1802,"email":16,"biography":1803,"createdAt":1804,"updatedAt":1805,"url_path_id":1806,"contactPhoto":1807,"socialLinks":1836,"url_path":1837},"John Yates","The Scripps Research Institute, USA","\u003Cp style=\"text-align:justify;\">John R. Yates is the John Lytton Young Professor at Scripps Research. His research includes the development of integrated methods for tandem mass spectrometry analysis of protein mixtures, bioinformatics using mass spectrometry data, and biological studies involving proteomics. He is the lead inventor of the SEQUEST software for correlating tandem mass spectrometry data to sequences in the database and developer of the shotgun proteomics technique for the analysis of protein mixtures. His laboratory has developed proteomic techniques to analyze protein complexes, posttranslational modifications, organelles and quantitative analysis of protein expression for the study of biology. \u003C/p>","2025-06-03T16:04:01.925Z","2026-01-12T22:26:57.769Z","37",{"id":1808,"name":1809,"alternativeText":16,"caption":16,"width":1810,"height":1810,"formats":1811,"hash":1832,"ext":1721,"mime":1297,"size":1833,"url":1834,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":1835,"updatedAt":1835},115,"City background.jpeg",1024,{"large":1812,"small":1817,"medium":1822,"thumbnail":1827},{"ext":1721,"url":1813,"hash":1814,"mime":1297,"name":1815,"path":16,"size":1816,"width":41,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_City_background_2cf47e1769.jpeg","large_City_background_2cf47e1769","large_City background.jpeg",101.05,{"ext":1721,"url":1818,"hash":1819,"mime":1297,"name":1820,"path":16,"size":1821,"width":48,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_City_background_2cf47e1769.jpeg","small_City_background_2cf47e1769","small_City background.jpeg",29.36,{"ext":1721,"url":1823,"hash":1824,"mime":1297,"name":1825,"path":16,"size":1826,"width":55,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_City_background_2cf47e1769.jpeg","medium_City_background_2cf47e1769","medium_City background.jpeg",59.78,{"ext":1721,"url":1828,"hash":1829,"mime":1297,"name":1830,"path":16,"size":1831,"width":937,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_City_background_2cf47e1769.jpeg","thumbnail_City_background_2cf47e1769","thumbnail_City background.jpeg",5.27,"City_background_2cf47e1769",107.23,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/City_background_2cf47e1769.jpeg","2026-01-12T22:26:35.075Z",[],"-12","-79",{"id":276,"session":1840},{"id":276,"title":1841,"teaser":1842,"body":1843,"createdAt":1844,"updatedAt":1845,"publishedAt":1846,"url_path_id":1847,"contacts":1848,"url_path":1882},"Recent progress in high-performance sample preparation techniques","\u003Cp style=\"text-align:justify;\">Sample preparation constitutes the initial and often most critical stage in the analysis of complex sample, fundamentally determines the overall performance of analytical method. However, by guiding substances from mess to order, sample preparation cannot occur automatically and spontaneously, frequently constitutes the rate-limiting step in complex analytical workflows. \u003C/p>","\u003Cp style=\"text-align:justify;\">To improve the efficiency of sample preparation and thereby advance analytical performance in terms of selectivity, sensitivity, stability, speed, accuracy, automation, application and sustainability, a variety of high-performance approaches have been developed in recent years. Herein, the recent progress in high-performance sample preparation strategies has been classified into four principal categories. By employing functional materials in sample preparation, sensitive and selective detection can be achieved. Chemical conversion and biological recognition can further enhance the selectivity and sensitivity of analytical methods. The introduction of additional energy fields can accelerate the separation process. Additionally, the development of advanced devices allows for automated sample analysis with improved speed and accuracy. Typical high-performance sample preparation techniques are also highlighted. Furthermore, future trends focus on enhancing the performance of sample preparation and effectively integrating it with detection processes to achieve high-performance analysis.\u003C/p>","2026-01-12T22:37:07.244Z","2026-01-12T22:38:50.756Z","2026-01-12T22:38:50.751Z","111",[1849],{"id":14,"name":1850,"committee":16,"position":16,"affiliation":1851,"email":16,"biography":1852,"createdAt":1853,"updatedAt":1854,"url_path_id":1855,"contactPhoto":1856,"socialLinks":1880,"url_path":1881},"Gongke Li","Sun Yat-sen University, China","\u003Cp style=\"text-align:justify;\">Professor Gongke Li obtained her Ph.D. in Analytical Chemistry from Sun Yat-sen University in 1992. She then joined Sun Yat-sen University and has been a professor since 2000. Her major research advances include the establishment of fairly systematic modern sample preparation techniques based on the exploitation of various novel and/or unique materials, novel devices and applications of them to the analysis of trace composition in complex systems, such as foods, drugs, environmental samples, and biological samples. She has published more than 520 peer-refereed journal articles, 4 books and more than 65 patents for invention. Recently, rapid detection of complex samples has gained fast development in her group. She was awarded the Chinese Women’s Analytical Chemist in 2015 and the Chromatographic Contribution Award of China in 2023. She was also named as one of the 2016 Power List and the Top 50 most influential women, the 2019 and 2021 Power List as one of the Top 100 most influential people in analytical science in the world by The Analytical Scientist. She is currently the Editor of Journal of Chromatography A.\u003C/p>","2025-06-03T15:44:37.465Z","2026-01-12T22:36:07.882Z","33",{"id":1465,"name":1857,"alternativeText":16,"caption":16,"width":55,"height":41,"formats":1858,"hash":1876,"ext":1294,"mime":1297,"size":1877,"url":1878,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":1879,"updatedAt":1879},"large_Gongke_LI_1_7504e86141.jpg",{"small":1859,"medium":1865,"thumbnail":1871},{"ext":1294,"url":1860,"hash":1861,"mime":1297,"name":1862,"path":16,"size":1863,"width":1864,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_large_Gongke_LI_1_7504e86141_a3dabc2e6a.jpg","small_large_Gongke_LI_1_7504e86141_a3dabc2e6a","small_large_Gongke_LI_1_7504e86141.jpg",14.77,375,{"ext":1294,"url":1866,"hash":1867,"mime":1297,"name":1868,"path":16,"size":1869,"width":1870,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_large_Gongke_LI_1_7504e86141_a3dabc2e6a.jpg","medium_large_Gongke_LI_1_7504e86141_a3dabc2e6a","medium_large_Gongke_LI_1_7504e86141.jpg",29.08,563,{"ext":1294,"url":1872,"hash":1873,"mime":1297,"name":1874,"path":16,"size":1875,"width":632,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_large_Gongke_LI_1_7504e86141_a3dabc2e6a.jpg","thumbnail_large_Gongke_LI_1_7504e86141_a3dabc2e6a","thumbnail_large_Gongke_LI_1_7504e86141.jpg",2.64,"large_Gongke_LI_1_7504e86141_a3dabc2e6a",47.3,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Gongke_LI_1_7504e86141_a3dabc2e6a.jpg","2025-06-03T15:44:35.236Z",[],"-8","-80",{"id":288,"session":1884},{"id":288,"title":1885,"teaser":1886,"body":1887,"createdAt":1888,"updatedAt":1889,"publishedAt":1890,"url_path_id":1891,"contacts":1892,"url_path":1916},"Modern size-exclusion chromatography as a versatile tool for characterizing a wide range of innovative drug modalities","\u003Cp style=\"text-align:justify;\">In recent years, the pharmaceutical drug landscape has rapidly evolved beyond traditional small molecules and therapeutic antibodies, with an increasing importance from therapeutic peptides and oligonucleotides (“TIDES”). Concurrently, the fast development of cell and gene therapy (CGT) approaches led to the introduction of complex genome editing materials such as guide RNAs (gRNAs), mRNAs, Cas enzyme and recombinant adeno-associated viruses (rAAVs). Several of these emerging drug modalities and CGT approaches have demonstrated remarkable clinical success and are now marketed. \u003Cbr> \u003C/p>","\u003Cp style=\"text-align:justify;\">These emerging drug modalities present a wide range of physicochemical properties and are particularly susceptible to various modifications during manufacturing and storage. Such changes may compromise therapeutic efficacy, increase toxicity or result in adverse side effects in patients. Consequently, comprehensive characterization of these molecules is essential and requires the use of multiple complementary analytical techniques to assess their quality attributes. Aggregates are a known impurity of concern in protein-based products, while their impact in nucleic acidbased products remains under investigation. Their assessment is critical for safety and mechanistic understanding.\u003C/p>\u003Cp style=\"text-align:justify;\">Size exclusion chromatography (SEC) is the reference technique for aggregation determination and possibly fragmentation and is well adapted for the QC environment. SEC is a non-denaturing chromatographic technique that separates analytes according to their hydrodynamic radius, in the absence of chemical interactions with the packing material. \u003C/p>\u003Cp style=\"text-align:justify;\">The primary objective of this presentation is to propose a clear strategy for SEC method development using modern SEC columns and to evaluate the applicability of SEC to the characterization of the innovative biopharmaceutical products listed above. In recent years, we have extensively evaluated a broad range of recently commercialized SEC columns, including “classical” materials with pore sizes around 300 Å for mAbs and ADCs [1], columns with larger pore sizes (approximately 500 Å), and ultra-wide-pore SEC columns (around 1000 Å) for rAAVs and mRNA [2]. In addition, columns with smaller pore sizes in the range of 60–150 Å have been evaluated for therapeutic peptides and oligonucleotides [3].\u003C/p>\u003Cp style=\"text-align:justify;\">[1] A. Murisier, M. Andrie, S. Fekete, M. Lauber, V. D’Atri, K. Iwan, D. Guillarme, Journal of separation science, 2022,\u003Cbr>45, 1997-2007\u003Cbr>[2] M. Buff, A. Goyon, C. Elger, R. Ruppert, M. Haindl, K. Zhang, D. Guillarme, Journal of chromatography, 2026, 1752,\u003Cbr>465972\u003Cbr>[3] M. Buff, A. Goyon, K. Zhang, D. Guillarme, Journal of chromatography, 2026, In preparation \u003C/p>","2026-01-13T17:51:45.017Z","2026-02-06T16:36:17.586Z","2026-01-13T17:51:46.868Z","112",[1893],{"id":1278,"name":1894,"committee":16,"position":16,"affiliation":1895,"email":16,"biography":1896,"createdAt":1897,"updatedAt":1897,"url_path_id":1898,"contactPhoto":1899,"socialLinks":1914,"url_path":1915},"Davy Guillarme","University of Geneva, Switzerland","\u003Cp style=\"text-align:justify;\">Davy Guillarme, Ph.D. in analytical chemistry from the University of Lyon, France, currently serves as an associate professor at the University of Geneva in Switzerland. With over 370 published journal articles in pharmaceutical analysis and h-index of 83 (Google Scholar), his expertise spans various techniques, including HPLC, UHPLC, HILIC, LC−MS, SFC, SFC-MS, multidimensional LC, and the analysis of biopharmaceuticals. He is an editor of the Journal of Chromatography A and serves on the editorial advisory board of prestigious journals like Trends in Analytical Chemistry, Journal of Chromatography B, Journal of Separation Science, LC−GC International. Guillarme has been honored with the LC-GC Emerging Leader Award in Chromatography (2013), the Jubilee Medal from the Chromatographic Society (2018), the International Award of the Belgian Society of Pharmaceutical Sciences (2022) and the Csaba Horvath memorial award (2025). He has also been listed among the world's most influential analytical scientists by \"Analytical Scientist\" magazine in multiple years.\u003C/p>","2025-12-29T16:10:55.704Z","81",{"id":1416,"name":1900,"alternativeText":16,"caption":16,"width":1901,"height":1902,"formats":1903,"hash":1910,"ext":35,"mime":38,"size":1911,"url":1912,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":1913,"updatedAt":1913},"unnamed.png",457,423,{"thumbnail":1904},{"ext":35,"url":1905,"hash":1906,"mime":38,"name":1907,"path":16,"size":1908,"width":1909,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_unnamed_f085804ba9.png","thumbnail_unnamed_f085804ba9","thumbnail_unnamed.png",36.39,169,"unnamed_f085804ba9",61.37,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/unnamed_f085804ba9.png","2025-12-29T16:10:53.693Z",[],"-52","-81",{"id":270,"session":1918},{"id":270,"title":1919,"teaser":1920,"body":1921,"createdAt":1922,"updatedAt":1923,"publishedAt":1924,"url_path_id":1925,"contacts":1926,"url_path":1962},"AI-Augmented Liquid Chromatography-Mass Spectrometry in Metabolomics: Promoting methodological innovation and clinical translation","\u003Cp style=\"text-align:justify;\">Metabolomics, the systematic analysis of low-molecular-weight metabolites, is being revolutionized through the integration of artificial intelligence (AI) with advanced liquid chromatography-mass spectrometry (LC-MS) platforms. This presentation explores how AI transforms every aspect of the metabolomics workflow: from LC-MS-based data acquisition and feature extraction to metabolite annotation and biological interpretation\u003C/p>","\u003Cp style=\"text-align:justify;\">Facing the limitations of conventional untargeted LC-MS approaches, including slow data processing, batch effects, and low structural identification rates, we demonstrate how AI-enabled tools enhance throughput, reproducibility, data pretreatment and dark matter annotation efficiency. The emergence of standardized, automated, and intelligent \"third-generation\" metabolomicsbuilt on robust LC-MS methodologies in our laboratory-enables large-scale, high-coverage metabolic profiling. We further illustrate the clinical relevance of AI-enhanced LC-MS metabolomics through collaborative research on type 2 diabetes, obesity, and related metabolic diseases. By combining LC-MS data with multi-omics inputs, these studies identify novel biomarkers, uncover metabolic reprogramming patterns, and evaluate/suggest novel interventions such as dietary modulation, drug therapies, and surgery. This lecture will report these novel results. \u003C/p>","2026-01-15T16:06:44.861Z","2026-01-15T16:06:48.877Z","2026-01-15T16:06:48.871Z","114",[1927],{"id":122,"name":1928,"committee":16,"position":16,"affiliation":1929,"email":16,"biography":1930,"createdAt":1931,"updatedAt":1932,"url_path_id":1933,"contactPhoto":1934,"socialLinks":1960,"url_path":1961},"Guowang Xu","Dalian Institute of Chemical Physics, China","\u003Cp style=\"text-align:justify;\">Prof. Dr. Guowang Xu received his Ph.D in Dalian Institute of Chemical Physics, Chinese Academy of Sciences in Jun., 1991. He is the president of Chromatography Committee of Chinese Society of Chemistry, deputy director of the Environmental Exposure Science Committee of the Chinese Society for Environmental Sciences and council member of the Chinese Chemical Society.\u003C/p>\u003Cp style=\"text-align:justify;\">He has co-written 5 books and published 580+ peer-reviewed papers in the ‘Web of Science Core Collection’ (WoS) indexed journals including PNAS, Nature Protocols, Nature Commun., Nature Methods, Cell Metab., Advance Science, Hepatology, Cancer Res., Anal. Chem., etc., and holds more than 100 China patents. H-Index: 83 (WoS), 103 (Google).\u003C/p>\u003Cp style=\"text-align:justify;\">His main research fields are in the chromatography-mass spectrometry (MS) technique development and the MS-based bulk, single cell and spatial metabolomics/exposomics applications in disease typing, biomarker discovery and new treatment strategies, synthetic biology and food safety. \u003Cbr> \u003C/p>","2025-06-03T16:03:30.737Z","2026-01-15T16:04:26.162Z","36",{"id":1589,"name":1935,"alternativeText":16,"caption":16,"width":1936,"height":41,"formats":1937,"hash":1956,"ext":1294,"mime":1297,"size":1957,"url":1958,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":1959,"updatedAt":1959},"large_Pict_Otsuka_1_f7d2812ad5.jpg",800,{"small":1938,"medium":1944,"thumbnail":1950},{"ext":1294,"url":1939,"hash":1940,"mime":1297,"name":1941,"path":16,"size":1942,"width":1943,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_large_Pict_Otsuka_1_f7d2812ad5_1c299cc890.jpg","small_large_Pict_Otsuka_1_f7d2812ad5_1c299cc890","small_large_Pict_Otsuka_1_f7d2812ad5.jpg",22.82,400,{"ext":1294,"url":1945,"hash":1946,"mime":1297,"name":1947,"path":16,"size":1948,"width":1949,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_large_Pict_Otsuka_1_f7d2812ad5_1c299cc890.jpg","medium_large_Pict_Otsuka_1_f7d2812ad5_1c299cc890","medium_large_Pict_Otsuka_1_f7d2812ad5.jpg",48.36,600,{"ext":1294,"url":1951,"hash":1952,"mime":1297,"name":1953,"path":16,"size":1954,"width":1955,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_large_Pict_Otsuka_1_f7d2812ad5_1c299cc890.jpg","thumbnail_large_Pict_Otsuka_1_f7d2812ad5_1c299cc890","thumbnail_large_Pict_Otsuka_1_f7d2812ad5.jpg",3.37,125,"large_Pict_Otsuka_1_f7d2812ad5_1c299cc890",84.5,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Pict_Otsuka_1_f7d2812ad5_1c299cc890.jpg","2025-06-03T16:03:24.817Z",[],"-11","-82",{"id":548,"session":1964},{"id":548,"title":1965,"teaser":1966,"body":1967,"createdAt":1968,"updatedAt":1969,"publishedAt":1970,"url_path_id":1971,"contacts":1972,"url_path":2012},"3D printed microfluidic chromatography columns for solid-phase extraction","\u003Cp style=\"text-align:justify;\">3D printing allows the custom creation of miniaturized structures with three-dimensional complexity. We have developed stereolithographic 3D printers that can make devices containing components such as pumps and valves to control fluid transport in microfluidic channels [1], enabling a broad range of bioassays. Recently, we have focused on 3D printing of chromatographic columns within these microfluidic systems, for improved sample preparation capabilities compared to forming columns in devices after their fabrication.\u003C/p>","\u003Cp style=\"text-align:justify;\">Our initial efforts have been directed at making and testing affinity solid-phase extraction (SPE) columns. Using a previously reported 3D printer [1], we have created microstructured pillars within 3D printed microfluidic systems and derivatized them with DNA for hybridization-based nucleic acid extraction. We are also utilizing a newly developed, dual-resolution 3D printer [2] that can form three-dimensional features as small as 2 µm for chromatography columns in immunoaffinity SPE devices. We have studied the formation of these chromatographic columns and their derivatization with antibodies for immunoaffinity SPE. We have also evaluated print design, resin composition and 3D printing settings in optimizing column construction and performance. Importantly, we have demonstrated the ability to enrich a model protein, RFP, using these 3D printed immunoaffinity SPE devices. We are currently expanding the breadth of analytes that can be extracted in these devices and evaluating other SPE column functionalities. The use of 3D printing to create chromatographic media with improved performance characteristics offers excellent potential to advance separation science.\u003C/p>\u003Cp style=\"text-align:justify;\">References:\u003Cbr>[1] Sanchez Noriega, J.L. et al. Nat. Comm. 12, 5509 (2021).\u003Cbr>[2] Miner, D.S. et al. Microsyst. Nanoengin. in press (2026).\u003C/p>","2026-01-20T18:50:58.978Z","2026-02-06T16:45:45.173Z","2026-01-20T18:51:00.286Z","117",[1973],{"id":150,"name":1974,"committee":16,"position":16,"affiliation":1975,"email":16,"biography":1976,"createdAt":1977,"updatedAt":1977,"url_path_id":1978,"contactPhoto":1979,"socialLinks":2010,"url_path":2011},"Adam Woolley","Brigham Young University","\u003Cp style=\"text-align:justify;\">Adam T. Woolley has been on the faculty at Brigham Young University in the Department of Chemistry and Biochemistry since 2000. He is currently University Professor and Dean of Graduate Studies. Prof. Woolley received a B.S. degree in chemistry from Brigham Young University in 1992 and a PhD in chemistry from the University of California-Berkeley in 1997. He was a Runyon-Winchell Postdoctoral Fellow in the Chemistry and Chemical Biology Department at Harvard University from 1998-2000. Dr. Woolley’s scholarship is directed at the interface between miniaturization and biomolecules. He develops microfluidic devices for chemical analysis with an emphasis on biomedically relevant assays, and he is utilizing biomolecules to self-assemble nanoscale electronic systems. His research has been funded by the US NIH, NSF, Department of Defense, and other private and government funding entities.\u003C/p>","2026-01-20T18:50:30.107Z","116",{"id":282,"name":1980,"alternativeText":16,"caption":16,"width":1981,"height":1982,"formats":1983,"hash":2006,"ext":1294,"mime":1297,"size":2007,"url":2008,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2009,"updatedAt":2009},"ATW photo credit Jessie O'Neal (1).jpg",4298,6447,{"large":1984,"small":1989,"medium":1995,"thumbnail":2000},{"ext":1294,"url":1985,"hash":1986,"mime":1297,"name":1987,"path":16,"size":1988,"width":1631,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_ATW_photo_credit_Jessie_O_Neal_1_31ea70355a.jpg","large_ATW_photo_credit_Jessie_O_Neal_1_31ea70355a","large_ATW photo credit Jessie O'Neal (1).jpg",146.19,{"ext":1294,"url":1990,"hash":1991,"mime":1297,"name":1992,"path":16,"size":1993,"width":1994,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_ATW_photo_credit_Jessie_O_Neal_1_31ea70355a.jpg","small_ATW_photo_credit_Jessie_O_Neal_1_31ea70355a","small_ATW photo credit Jessie O'Neal (1).jpg",39.02,334,{"ext":1294,"url":1996,"hash":1997,"mime":1297,"name":1998,"path":16,"size":1999,"width":48,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_ATW_photo_credit_Jessie_O_Neal_1_31ea70355a.jpg","medium_ATW_photo_credit_Jessie_O_Neal_1_31ea70355a","medium_ATW photo credit Jessie O'Neal (1).jpg",85.03,{"ext":1294,"url":2001,"hash":2002,"mime":1297,"name":2003,"path":16,"size":2004,"width":2005,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_ATW_photo_credit_Jessie_O_Neal_1_31ea70355a.jpg","thumbnail_ATW_photo_credit_Jessie_O_Neal_1_31ea70355a","thumbnail_ATW photo credit Jessie O'Neal (1).jpg",4.71,104,"ATW_photo_credit_Jessie_O_Neal_1_31ea70355a",5951.02,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/ATW_photo_credit_Jessie_O_Neal_1_31ea70355a.jpg","2026-01-20T18:50:05.296Z",[],"-84","-85",{"id":206,"session":2014},{"id":206,"title":2015,"teaser":2016,"body":2017,"createdAt":2018,"updatedAt":2019,"publishedAt":2020,"url_path_id":2021,"contacts":2022,"url_path":2061},"An In-Depth, Label-Free Single-Cell Proteome Every 5 minutes or Less","\u003Cp style=\"text-align:justify;\">Biological tissues are highly heterogeneous, consisting of a variety of cell types, states and subpopulations, and understanding heterogeneity at the single cell level is of great interest for biomedical research. We have developed approaches to minimize sample losses normally incurred during sample processing. In combination ultra-low-flow separations and latest-generation mass spectrometry instrumentation, we now achieve in-depth proteome coverage for low-input samples including single cells. \u003C/p>","\u003Cp style=\"text-align:justify;\">We can quantify >5000 proteins from single mammalian cells and achieve similar coverage for frozen and formalin-fixed, paraffin-embedded tissue regions as small as 50 µm. I will describe advances in cell isolation, sample preparation, ultrasensitive separations, MS acquisition and data analysis that have made this possible, as well as efforts to minimize or eliminate the need for custom instrumentation for such analyses. Finally, we will present on a dual column nanoLC platform that enables in-depth proteome profiling of single cells samples at a rate of one single cell every ~3 minutes (500 samples per day) in a label-free analysis.\u003C/p>","2026-01-20T20:06:12.787Z","2026-02-06T16:38:05.600Z","2026-01-20T20:06:14.448Z","122",[2023],{"id":2024,"name":2025,"committee":16,"position":16,"affiliation":1975,"email":16,"biography":2026,"createdAt":2027,"updatedAt":2027,"url_path_id":2028,"contactPhoto":2029,"socialLinks":2059,"url_path":2060},44,"Ryan Kelly","\u003Cp style=\"text-align:justify;\">Ryan Kelly is a professor in the Department of Chemistry and Biochemistry at Brigham Young University. His recent research efforts have focused on single-cell and spatial proteomics, which have involved tailoring sample preparation (e.g., nanoPOTS), separations, ionization and mass spectrometry acquisition for low-input samples. His group’s efforts have enabled thousands of proteins to be rapidly profiled from single cells. He is now working to dramatically lower the cost of proteomics, with the ultimate goal of profiling any biological sample for just ~$10.\u003C/p>","2026-01-20T20:05:02.089Z","121",{"id":2030,"name":2031,"alternativeText":16,"caption":16,"width":2032,"height":2033,"formats":2034,"hash":2055,"ext":1294,"mime":1297,"size":2056,"url":2057,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2058,"updatedAt":2058},122,"RYAN KELLY-1.jpg",2504,3756,{"large":2035,"small":2040,"medium":2045,"thumbnail":2050},{"ext":1294,"url":2036,"hash":2037,"mime":1297,"name":2038,"path":16,"size":2039,"width":1631,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_RYAN_KELLY_1_ab0f35c987.jpg","large_RYAN_KELLY_1_ab0f35c987","large_RYAN KELLY-1.jpg",72.97,{"ext":1294,"url":2041,"hash":2042,"mime":1297,"name":2043,"path":16,"size":2044,"width":1637,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_RYAN_KELLY_1_ab0f35c987.jpg","small_RYAN_KELLY_1_ab0f35c987","small_RYAN KELLY-1.jpg",24.03,{"ext":1294,"url":2046,"hash":2047,"mime":1297,"name":2048,"path":16,"size":2049,"width":48,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_RYAN_KELLY_1_ab0f35c987.jpg","medium_RYAN_KELLY_1_ab0f35c987","medium_RYAN KELLY-1.jpg",45.16,{"ext":1294,"url":2051,"hash":2052,"mime":1297,"name":2053,"path":16,"size":2054,"width":2005,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_RYAN_KELLY_1_ab0f35c987.jpg","thumbnail_RYAN_KELLY_1_ab0f35c987","thumbnail_RYAN KELLY-1.jpg",4.22,"RYAN_KELLY_1_ab0f35c987",589.47,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/RYAN_KELLY_1_ab0f35c987.jpg","2026-01-20T20:04:47.500Z",[],"-88","-89",{"id":306,"session":2063},{"id":306,"title":2064,"teaser":2065,"body":2066,"createdAt":2067,"updatedAt":2068,"publishedAt":2069,"url_path_id":2070,"contacts":2071,"url_path":2115},"Bioinert UHPSFC/MS in Comprehensive Lipidomic Quantitation","\u003Cp style=\"text-align:justify;\">Comprehensive lipidomic quantitation remains analytically demanding due to the large structural diversity of lipids, their broad polarity range, and concentration differences spanning several orders of magnitude. Although UHPLC/MS is widely used, limitations in lipidome coverage and analysis time remain. Ultrahigh-performance supercritical fluid chromatography–mass spectrometry (UHPSFC/MS) offers a high-throughput alternative, but its broader application to highly polar and ionic lipid classes has been restricted by undesired interactions with metal surfaces, leading to peak tailing and sensitivity loss. Here, we present a UHPSFC/MS method using a bioinert column, which enables fast, robust, and comprehensive quantitative lipidomic analysis for nonpolar, polar, and ionic lipid classes.\u003C/p>","\u003Cp style=\"text-align:justify;\">The separation was performed using supercritical CO₂ with a methanol-based modifier containing volatile additives, achieving class-based separation of 37 lipid classes within 7.5 min, including re-equilibration [1]. The bioinert column configuration suppressed interactions of phosphate-containing lipids with metal surfaces, resulting in significantly improved peak symmetry and enhanced sensitivity. The sample preparation combined modified MTBE extraction with a selective hexane elimination step to reduce excessive nonpolar lipids while preserving polar and ionic species. The quantitation employed class-specific internal standards and LipidQuant 2.1 software [2]. The method was validated according to bioanalytical guidelines using NIST SRM 1950 human plasma. Measured concentrations showed good agreement with interlaboratory consensus values, confirming accuracy and robustness. The optimized workflow enabled confident identification of >650 lipid species in human plasma, tissues, erythrocytes, and cell lines. In addition to the class-based UHPSFC/MS method, a complementary reversed-phase (RP)-UHPSFC/MS approach was developed to enhance lipid species separation and the isomeric resolution of less polar classes, further extending analytical coverage. The bioinert UHPSFC/MS platform demonstrates that the comprehensive lipid class separation, including analytically challenging ionic species (e.g., phosphatidic acids, lysophosphatidic acids, ceramide phosphates, sphingoid base phosphates), can be achieved within a single short run. This methodology provides high-throughput lipidomic quantitation for large-scale studies, as illustrated by the example of lipidomic analysis of human plasma in cancer biomarker research [3]. The multivariate data analysis models for classification of pancreatic cancer patients and healthy controls allow their differentiation with sensitivity and specificity above 95%. This work was supported by ERC AdG No. 101095860.\u003C/p>","2026-01-20T21:02:31.695Z","2026-02-18T20:39:43.240Z","2026-01-20T21:02:32.911Z","124",[2072],{"id":306,"name":2073,"committee":16,"position":16,"affiliation":2074,"email":16,"biography":2075,"createdAt":2076,"updatedAt":2077,"url_path_id":2078,"contactPhoto":2079,"socialLinks":2113,"url_path":2114},"Michal Holčapek","University of Pardubice, Czech Republic","\u003Cp style=\"text-align:justify;\">Michal Holčapek obtained his Ph.D. in analytical chemistry from the University of Pardubice (1999), where he currently serves as a professor of analytical chemistry. His research focuses on mass spectrometry and its coupling with liquid chromatography or supercritical fluid chromatography, applied mainly to lipidomic analysis and cancer biomarker research. He has received numerous prestigious awards, including the Neuron Award for Connecting Science and Business (2023, Neuron Foundation), the Rudolf Lukeš Prize (2023, Experientia Foundation), and the Herbert J. Dutton Award (2022, American Oil Chemists' Society). He has also been repeatedly recognized on the Analytical Scientist Power List of the most influential people in analytical science since 2019. He is one of the founding members of the Lipidomics Standards Initiative and the International Lipidomics Society.\u003C/p>","2025-11-07T17:27:07.338Z","2026-01-20T21:01:12.075Z","62",{"id":2080,"name":2081,"alternativeText":16,"caption":16,"width":2082,"height":2083,"formats":2084,"hash":2109,"ext":1294,"mime":1297,"size":2110,"url":2111,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2112,"updatedAt":2112},124,"Holcapek_head_photo_2024.jpg",2651,2910,{"large":2085,"small":2091,"medium":2097,"thumbnail":2103},{"ext":1294,"url":2086,"hash":2087,"mime":1297,"name":2088,"path":16,"size":2089,"width":2090,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Holcapek_head_photo_2024_1f986096d3.jpg","large_Holcapek_head_photo_2024_1f986096d3","large_Holcapek_head_photo_2024.jpg",112.72,911,{"ext":1294,"url":2092,"hash":2093,"mime":1297,"name":2094,"path":16,"size":2095,"width":2096,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Holcapek_head_photo_2024_1f986096d3.jpg","small_Holcapek_head_photo_2024_1f986096d3","small_Holcapek_head_photo_2024.jpg",27.56,455,{"ext":1294,"url":2098,"hash":2099,"mime":1297,"name":2100,"path":16,"size":2101,"width":2102,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Holcapek_head_photo_2024_1f986096d3.jpg","medium_Holcapek_head_photo_2024_1f986096d3","medium_Holcapek_head_photo_2024.jpg",62.35,683,{"ext":1294,"url":2104,"hash":2105,"mime":1297,"name":2106,"path":16,"size":2107,"width":2108,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Holcapek_head_photo_2024_1f986096d3.jpg","thumbnail_Holcapek_head_photo_2024_1f986096d3","thumbnail_Holcapek_head_photo_2024.jpg",3.59,142,"Holcapek_head_photo_2024_1f986096d3",1033.85,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Holcapek_head_photo_2024_1f986096d3.jpg","2026-01-20T21:01:09.788Z",[],"-35","-90",{"id":168,"session":2117},{"id":168,"title":2118,"teaser":2119,"body":2120,"createdAt":2121,"updatedAt":2122,"publishedAt":2123,"url_path_id":2124,"contacts":2125,"url_path":2163},"Analytical Techniques for the Characterization of Oligonucleotide Therapeutics","\u003Cp style=\"text-align:justify;\">Synthetic oligonucleotides are a novel class of drugs with the potential to treat a wide spectrum of indications, including cancer, cardiovascular and metabolic conditions, neurological disorders, and ophthalmic diseases. Several oligonucleotide drugs have recently been approved, and a greater number are in clinical trials. Discovery, development, and manufacturing of synthetic oligonucleotides necessitate analysis of the main drug component and its impurities by appropriate analytical techniques.\u003C/p>","\u003Cp style=\"text-align:justify;\">Methods will be presented for the characterization of oligonucleotide therapeutics and their impurities using chromatographic and mass spectrometric tools.\u003C/p>","2026-01-21T21:53:54.381Z","2026-03-24T17:57:36.051Z","2026-01-21T21:54:02.565Z","127",[2126],{"id":1531,"name":2127,"committee":16,"position":16,"affiliation":2128,"email":16,"biography":2129,"createdAt":2130,"updatedAt":2130,"url_path_id":2131,"contactPhoto":2132,"socialLinks":2161,"url_path":2162},"Claus Rentel","Ionis Pharmaceuticals, Inc.","\u003Cp style=\"text-align:justify;\">Dr. Rentel is currently Vice President, Analytical Development and Quality Control at Ionis Pharmaceuticals, Inc., Carlsbad, California. Prior to joining Ionis in 2001 he worked in Quality Control and Special Analytics at CarboGen in Switzerland. He received his Ph.D. (summa cum laude) from the University of Tuebingen, Germany.\u003C/p>\u003Cp style=\"text-align:justify;\">Dr. Rentel has more than 25 years of experience in Quality Control. He has extensive expertise in the CMC development of oligonucleotide therapeutics and is an expert in mass spectrometric techniques. He has been responsible for IND filings of more than 60 oligonucleotides and participated in the NDA filings for the approved oligonucleotide drugs KYNAMRO®, SPINRAZATM, WAYLIVRA®, TEGSEDITM, WAINUATM, TRYNGOLZATM, and DAWNZERATM.\u003Cbr> \u003C/p>","2026-01-21T21:53:22.626Z","126",{"id":2133,"name":2134,"alternativeText":16,"caption":16,"width":2135,"height":2136,"formats":2137,"hash":2157,"ext":1294,"mime":1297,"size":2158,"url":2159,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2160,"updatedAt":2160},126,"23_CSP_Claus-Rentel_3732-Edit-web.jpg",2000,1333,{"large":2138,"small":2143,"medium":2148,"thumbnail":2153},{"ext":1294,"url":2139,"hash":2140,"mime":1297,"name":2141,"path":16,"size":2142,"width":41,"height":1631},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61.jpg","large_23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61","large_23_CSP_Claus-Rentel_3732-Edit-web.jpg",38.23,{"ext":1294,"url":2144,"hash":2145,"mime":1297,"name":2146,"path":16,"size":2147,"width":48,"height":1637},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61.jpg","small_23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61","small_23_CSP_Claus-Rentel_3732-Edit-web.jpg",12.18,{"ext":1294,"url":2149,"hash":2150,"mime":1297,"name":2151,"path":16,"size":2152,"width":55,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61.jpg","medium_23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61","medium_23_CSP_Claus-Rentel_3732-Edit-web.jpg",23.43,{"ext":1294,"url":2154,"hash":2155,"mime":1297,"name":2156,"path":16,"size":1743,"width":1648,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61.jpg","thumbnail_23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61","thumbnail_23_CSP_Claus-Rentel_3732-Edit-web.jpg","23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61",197.21,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/23_CSP_Claus_Rentel_3732_Edit_web_6a896d8e61.jpg","2026-01-21T21:53:08.605Z",[],"-92","-93",{"id":238,"session":2165},{"id":238,"title":2166,"teaser":2167,"body":2168,"createdAt":2169,"updatedAt":2170,"publishedAt":2171,"url_path_id":2172,"contacts":2173,"url_path":2216},"Exploring one- and multidimensional chromatography in biopharmaceutical analysis: from simple set-ups to separation masterpieces","\u003Cp style=\"text-align:justify;\">Monoclonal antibodies (mAbs) leverage the immune system’s natural precision to target disease pathways with high specificity and have become a major force in the pharmaceutical industry. Their success has spurred the development of various next-generation formats such as antibody-drug conjugates (ADCs), bispecific antibodies (bsAbs), antibody fragments, Fc fusion proteins, etc. With vast therapeutic potential comes an immense structural and functional intricacy highly demanding towards analytics.\u003C/p>","\u003Cp style=\"text-align:justify;\">This contribution will reflect on recent advances in liquid chromatography to investigate these study objects in great detail. Topics covered will include high performance affinity chromatography, affinity resolved size exclusion chromatography with multi-angle light scattering detection, low adsorption flow paths, the coupling of historical incompatible chromatographic methods with mass spectrometry, and the combination of ever more separation modes in multidimensional set-ups - optionally incorporating chemical or enzymatic reactors - to streamline characterization.\u003C/p>","2026-01-26T20:42:20.406Z","2026-03-13T20:28:46.671Z","2026-01-26T20:42:21.965Z","133",[2174],{"id":432,"name":2175,"committee":16,"position":16,"affiliation":2176,"email":16,"biography":2177,"createdAt":2178,"updatedAt":2178,"url_path_id":2179,"contactPhoto":2180,"socialLinks":2214,"url_path":2215},"Koen Sandra","RIC Group & Ghent University ","\u003Cp style=\"text-align:justify;\">Koen Sandra received a PhD degree in Biochemistry from the Ghent University, Belgium in 2005. After his PhD, he joined Pronota, a molecular diagnostics company where he was active in developing analytical platforms for disease biomarker discovery and in setting up external collaborations. In 2008, he joined RIC, a company that provides analytical support to the chemical, life sciences and pharmaceutical industries, where he holds the position of CEO. As a non-academic scientist, Koen Sandra is author of over 50 highly cited scientific papers and has presented his work at numerous conferences as an invited speaker. \u003C/p>","2026-01-26T20:42:06.668Z","132",{"id":2181,"name":2182,"alternativeText":16,"caption":16,"width":2183,"height":2184,"formats":2185,"hash":2210,"ext":1294,"mime":1297,"size":2211,"url":2212,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2213,"updatedAt":2213},131,"Picture Koen 1.jpg",1767,2227,{"large":2186,"small":2192,"medium":2198,"thumbnail":2204},{"ext":1294,"url":2187,"hash":2188,"mime":1297,"name":2189,"path":16,"size":2190,"width":2191,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Picture_Koen_1_8e43cb8803.jpg","large_Picture_Koen_1_8e43cb8803","large_Picture Koen 1.jpg",97.57,793,{"ext":1294,"url":2193,"hash":2194,"mime":1297,"name":2195,"path":16,"size":2196,"width":2197,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Picture_Koen_1_8e43cb8803.jpg","small_Picture_Koen_1_8e43cb8803","small_Picture Koen 1.jpg",29.35,397,{"ext":1294,"url":2199,"hash":2200,"mime":1297,"name":2201,"path":16,"size":2202,"width":2203,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Picture_Koen_1_8e43cb8803.jpg","medium_Picture_Koen_1_8e43cb8803","medium_Picture Koen 1.jpg",59.52,595,{"ext":1294,"url":2205,"hash":2206,"mime":1297,"name":2207,"path":16,"size":2208,"width":2209,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Picture_Koen_1_8e43cb8803.jpg","thumbnail_Picture_Koen_1_8e43cb8803","thumbnail_Picture Koen 1.jpg",4.6,123,"Picture_Koen_1_8e43cb8803",419.37,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Picture_Koen_1_8e43cb8803.jpg","2026-01-26T20:41:18.446Z",[],"-98","-99",{"id":363,"session":2218},{"id":363,"title":2219,"teaser":2220,"body":2221,"createdAt":2222,"updatedAt":2223,"publishedAt":2224,"url_path_id":2225,"contacts":2226,"url_path":2268},"Towards Precision Design and Manufacture of Chromatographic Material","\u003Cp style=\"text-align:justify;\">The development of chromatography material plays a central role in the advancement of separation science and purification technology, and have significant impact on life science discovery and pharmaceutical R&D and productions. Over the past 20 years, new generations of particulate materials, such as sub-2 micron particles, core-shell particles, and colloidal crystals, have remarkably expanded the kinetic performance limits. Additionally, the development of novel stationary phases in HILIC, mixed-mode chromatography, and chiral chromatography has significantly broadened HPLC's capabilities. \u003Cbr> \u003C/p>","\u003Cp style=\"text-align:justify;\">However, improvements in the separation efficiency and selectivity of chromatographic materials have always been fraught with randomness and trial-and-error. The key to overcoming these bottlenecks is the precise design and manufacture of chromatographic materials — considering morphology, pore structure, and chemistry.\u003C/p>\u003Cp style=\"text-align:justify;\">In this lecture, I am going to present our efforts in precision manufacturing of chromatographic materials, including high-precision production of particulate materials with controlled morphology, pore structure, and stationary phase distribution, based on a droplet microfluidic platform. I will also introduce a further expansion of this platform — by integrating micelle-templated selfassembly to engineer ordered mesoporous chromatographic materials, and by generating Janus droplets to construct spatially resolved stationary phases. These tailored materials are expected to offer unprecedented possibilities for investigating chromatographic kinetics or thermodynamics.\u003C/p>\u003Cp style=\"text-align:justify;\">Starting since last century, chromatographic materials are always an area enjoying everlasting development. Beyond pushing the boundaries of HPLC efficiency and applications, we believe that bottom-up engineering of chromatographic material, leveraging the latest microfabrication tools and nanotechnologies, can eventually transform the manufacturing process of chromatographic columns from an \"art\" to a \"science\".\u003C/p>\u003Cp style=\"text-align:justify;\">References\u003Cbr>1, Bo Zhang et al. Angewandte Chemie International Edition, 2025, 64, e202418642.\u003Cbr>2, Bo Zhang et al. Nature Communications, 2026, DOI: 10.1038/s41467-026-68362-y \u003C/p>","2026-01-29T21:42:28.952Z","2026-02-06T16:48:16.538Z","2026-01-29T21:42:31.267Z","135",[2227],{"id":2228,"name":2229,"committee":16,"position":16,"affiliation":2230,"email":16,"biography":2231,"createdAt":2232,"updatedAt":2232,"url_path_id":2233,"contactPhoto":2234,"socialLinks":2266,"url_path":2267},50,"Bo Zhang","Xiamen University, China","\u003Cp style=\"text-align:justify;\">Bo Zhang, Professor at Xiamen University, China; Fellow of Royal Society of Chemistry; Jubilee Medalist of The Chromatographic Society; Scientific Committee Member of HPLC2025; Associate Editor of Journal of Separation Science. Editorial Board Member of Journal of Chromatography A and Chinese Journal of Chromatography. His training in separation science began in 1999 at the National Chromatographic Centre, part of the Dalian Institute of Chemical Physics. He pursued a PhD in chromatography at the University of York in the UK from 2002 to 2007, followed by two years of postdoctoral research at Imperial College London. Since 2009, he has been at Xiamen University, where he leads a research group specializing in chromatography. His team's work focuses on column technology, the development of advanced chromatographic materials, and microfluidic systems for bioseparations.\u003C/p>","2026-01-29T21:41:28.051Z","134",{"id":2235,"name":2236,"alternativeText":16,"caption":16,"width":1391,"height":2237,"formats":2238,"hash":2262,"ext":1294,"mime":1297,"size":2263,"url":2264,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2265,"updatedAt":2265},132,"Bo Zhang.jpg",2102,{"large":2239,"small":2245,"medium":2251,"thumbnail":2257},{"ext":1294,"url":2240,"hash":2241,"mime":1297,"name":2242,"path":16,"size":2243,"width":2244,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Bo_Zhang_15d02e71fe.jpg","large_Bo_Zhang_15d02e71fe","large_Bo Zhang.jpg",71.22,714,{"ext":1294,"url":2246,"hash":2247,"mime":1297,"name":2248,"path":16,"size":2249,"width":2250,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Bo_Zhang_15d02e71fe.jpg","small_Bo_Zhang_15d02e71fe","small_Bo Zhang.jpg",19.59,357,{"ext":1294,"url":2252,"hash":2253,"mime":1297,"name":2254,"path":16,"size":2255,"width":2256,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Bo_Zhang_15d02e71fe.jpg","medium_Bo_Zhang_15d02e71fe","medium_Bo Zhang.jpg",41.01,535,{"ext":1294,"url":2258,"hash":2259,"mime":1297,"name":2260,"path":16,"size":2261,"width":1433,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Bo_Zhang_15d02e71fe.jpg","thumbnail_Bo_Zhang_15d02e71fe","thumbnail_Bo Zhang.jpg",3.17,"Bo_Zhang_15d02e71fe",271.83,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Bo_Zhang_15d02e71fe.jpg","2026-01-29T21:41:24.371Z",[],"-100","-101",{"id":73,"session":2270},{"id":73,"title":2271,"teaser":2272,"body":2273,"createdAt":2274,"updatedAt":2275,"publishedAt":2276,"url_path_id":2277,"contacts":2278,"url_path":2309},"IP-RP-HRAM MS Profiling of DNA- and RNA-based antisense oligonucleotides: from production to in-vitro biotransformation ","\u003Cp style=\"text-align:justify;\">Oligonucleotide-based therapeutics market is experiencing rapid expansion, projected to reach over USD 17-51 billion by the early 2030s with a high CAGR of nearly 20%. Driven by advancements in RNA-targeted therapies, such as siRNA and antisense oligonucleotides (ASOs), this market is shifting from niche, rare disease applications to broader indications like oncology and chronic diseases. Nonetheless, this new class of therapeutics poses new challenges to the biopharma industry as it requires the support of robust and sensitive analytical methods.\u003C/p>","\u003Cp style=\"text-align:justify;\">Among the critical quality attributes that need to be assessed during production and on batch release, the primary structure of the oligomer together with the analysis of the 5′ and 3′ termini, and any site-specific modifications are of key interest to maintain quality, safety and efficacy of the final products. To assess these features, ion pairing reversed phased chromatography with high resolution accurate mass detection (IP-RP-HRAM MS) can enable a streamlined impurity profiling that enables identity confirmation of the target product, as well as monitoring and identification of impurities with high sensitivity. In this context, the variety of ion pairing reagents available to the analysts can massively influence method performance and it has never been fully investigated. In this study, we assessed weak, medium and strong ion pairing reagents using a novel macroporus monodisperse reversed phase column for the impurity profiling of multiple ASOs of different classes and presenting different modification on the oligonucleotide backbone. The chromatographic separation was hyphenated to Orbitrap mass spectrometry where MS/MS data were acquired for sequencing of each component. A DoE approach was undertaken to assess the chromatographic condition considering as key factors diastereoisomers separation suppression, peak resolution and LOD/LOQ for target impurities depending on the molecule of interest, without sacrificing method throughput. Upon DoE conclusion, MS parameters were also optimized to ensure absence of reduction of IP adducts, reproducibility and optimum fragmentation coverage for MS/MS analysis and confident identities confirmation. The optimized method will be employed for RNA- and DNA-based ASOs analysis as well as monitoring behaviour in-vitro of the products after incubation in plasma to assess the degradation pathways for the different generation of products.\u003C/p>","2026-02-03T13:58:02.214Z","2026-02-06T20:52:10.070Z","2026-02-03T13:58:03.936Z","139",[2279],{"id":1769,"name":2280,"committee":16,"position":16,"affiliation":2281,"email":16,"biography":2282,"createdAt":2283,"updatedAt":2284,"url_path_id":2285,"contactPhoto":2286,"socialLinks":2307,"url_path":2308},"Sara Carillo","National Institute for Bioprocessing Research and Training (NIBRT), Dublin, Ireland","\u003Cp style=\"text-align:justify;\">Dr. Sara Carillo completed her PhD in Chemical Sciences in 2013 at the University of Naples “Federico II” focusing on the structural characterization of polysaccharides and glycoconjugates from Gram-negative bacteria via NMR and mass spectrometry techniques. In 2015 she joined CCL group in NIBRT lead by Prof. Jonathan Bones. Sara started her postdoc working on the understanding of the effects of extractables and leachables from single-use bioreactors on CHO cells N-glycome and produced monoclonal antibodies. She is now working in NIBRT as Bioanalytical Research Lead and is mainly interested in the development on new mass spectrometry based analytical approaches to ensure deeper and easier understanding of biomanufacturing process and biopharmaceuticals structural complexity.\u003C/p>","2026-02-03T13:56:55.976Z","2026-02-03T14:15:32.765Z","138",{"id":2287,"name":2288,"alternativeText":16,"caption":16,"width":48,"height":2289,"formats":2290,"hash":2303,"ext":1294,"mime":1297,"size":2304,"url":2305,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2306,"updatedAt":2306},139,"Sara Carillo.jpg",514,{"small":2291,"thumbnail":2297},{"ext":1294,"url":2292,"hash":2293,"mime":1297,"name":2294,"path":16,"size":2295,"width":2296,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Sara_Carillo_66035230c0.jpg","small_Sara_Carillo_66035230c0","small_Sara Carillo.jpg",36.51,486,{"ext":1294,"url":2298,"hash":2299,"mime":1297,"name":2300,"path":16,"size":2301,"width":2302,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Sara_Carillo_66035230c0.jpg","thumbnail_Sara_Carillo_66035230c0","thumbnail_Sara Carillo.jpg",5.92,152,"Sara_Carillo_66035230c0",38.62,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Sara_Carillo_66035230c0.jpg","2026-02-03T14:15:28.430Z",[],"-104","-105",{"id":232,"session":2311},{"id":232,"title":2312,"teaser":2313,"body":2314,"createdAt":2315,"updatedAt":2316,"publishedAt":2317,"url_path_id":2318,"contacts":2319,"url_path":2359},"Advanced chromatographic strategies for comprehensivecharacterization of therapeutic peptides","\u003Cp style=\"text-align:justify;\">The clinical success of glucagon-like peptide-1 (GLP-1)–based therapeutics has renewed interest in peptide drugs for metabolic diseases, particularly obesity. Despite this momentum, analytical strategies for the comprehensive characterization of therapeutic peptides remain limited. This gap is notable given the structural and physicochemical diversity of therapeutic peptides, which include linear, macrocyclic, and disulfideconstrained formats and frequently incorporate unnatural amino acids.\u003C/p>","\u003Cp style=\"text-align:justify;\">Comprehensive characterization is a regulatory expectation to ensure patient safety, as reinforced by recent guidance such as the EMA Guideline on the Development and Manufacture of Synthetic Peptides (December 2025). Particular emphasis is placed on impurity profiling throughout manufacturing and shelf life, including truncation, substitution, and addition variants, as well as on peptide aggregation as a critical quality attribute. In this keynote lecture, we present a systematic evaluation of advanced chromatographic modes and their integration via two-dimensional liquid chromatography (2D-LC) for comprehensive impurity profiling of therapeutic peptides. Using reversed-phase liquid chromatography (RPLC), we demonstrate enhanced impurity detection with formic acid on a CSH Phenyl-Hexyl stationary phase compared to conventional trifluoroacetic acid. Beyond RPLC, we evaluate anion- and cation-exchange chromatography using BioPro and ProPac columns, comparing salt- and pH-gradient approaches. The addition of acetonitrile to the mobile phase was found to be essential to suppress nonspecific interactions and achieve robust separations. Finally, eleven size-exclusion chromatography (SEC) columns from six vendors, incorporating advanced bonding technologies, were assessed for peptide aggregate separation, highlighting the impact of column physical properties on performance. Together, these results illustrate how orthogonal and multidimensional chromatographic strategies can address current analytical gaps and support evolving regulatory expectations for therapeutic peptides.\u003C/p>","2026-02-03T14:07:49.352Z","2026-02-07T00:16:47.730Z","2026-02-03T14:07:51.236Z","141",[2320],{"id":2321,"name":2322,"committee":16,"position":16,"affiliation":2323,"email":16,"biography":2324,"createdAt":2325,"updatedAt":2325,"url_path_id":2326,"contactPhoto":2327,"socialLinks":2357,"url_path":2358},53,"Alexandre Goyon","Genentech","\u003Cp style=\"text-align:justify;\">Alexandre Goyon is a Principal Scientist in the Synthetic Molecule Pharmaceutical Sciences Organization of Genentech. He received a Ph.D. degree in pharmaceutical analytical chemistry in 2019 from the University of Geneva, Switzerland. He has developed multidimensional LC–MS methods and complementary approaches to support new drug modalities. Throughout his experiences at Nestle (Switzerland), Queen's University (Canada), University of Geneva (Switzerland), Novartis (Switzerland) and Genentech (United States), he has published 45 research articles, 8 reviews and 3 book chapters, including 36 as first author. His research has been recognized by several awards, including the Analytical Scientist \"Top 40 most influential people in analytical science under 40 years of age\", the ACS \"2024 Rising Star in Measurement Science\", and the Chinese American Chromatography Association (CACA) \"Young Investigator Award\". \u003C/p>","2026-02-03T14:07:21.275Z","140",{"id":2328,"name":2329,"alternativeText":16,"caption":16,"width":2330,"height":2331,"formats":2332,"hash":2353,"ext":1294,"mime":1297,"size":2354,"url":2355,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2356,"updatedAt":2356},137,"Alexandre Goyon 10-12-22 (2).jpg",3000,4500,{"large":2333,"small":2338,"medium":2343,"thumbnail":2348},{"ext":1294,"url":2334,"hash":2335,"mime":1297,"name":2336,"path":16,"size":2337,"width":1631,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Alexandre_Goyon_10_12_22_2_0cd227ce07.jpg","large_Alexandre_Goyon_10_12_22_2_0cd227ce07","large_Alexandre Goyon 10-12-22 (2).jpg",62.96,{"ext":1294,"url":2339,"hash":2340,"mime":1297,"name":2341,"path":16,"size":2342,"width":1994,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Alexandre_Goyon_10_12_22_2_0cd227ce07.jpg","small_Alexandre_Goyon_10_12_22_2_0cd227ce07","small_Alexandre Goyon 10-12-22 (2).jpg",19.77,{"ext":1294,"url":2344,"hash":2345,"mime":1297,"name":2346,"path":16,"size":2347,"width":48,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Alexandre_Goyon_10_12_22_2_0cd227ce07.jpg","medium_Alexandre_Goyon_10_12_22_2_0cd227ce07","medium_Alexandre Goyon 10-12-22 (2).jpg",38.43,{"ext":1294,"url":2349,"hash":2350,"mime":1297,"name":2351,"path":16,"size":2352,"width":2005,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Alexandre_Goyon_10_12_22_2_0cd227ce07.jpg","thumbnail_Alexandre_Goyon_10_12_22_2_0cd227ce07","thumbnail_Alexandre Goyon 10-12-22 (2).jpg",3.74,"Alexandre_Goyon_10_12_22_2_0cd227ce07",662.46,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Alexandre_Goyon_10_12_22_2_0cd227ce07.jpg","2026-02-03T14:07:01.696Z",[],"-106","-107",{"id":1278,"session":2361},{"id":1278,"title":2362,"teaser":2363,"body":2364,"createdAt":2365,"updatedAt":2366,"publishedAt":2367,"url_path_id":2368,"contacts":2369,"url_path":2411},"Multi-dimensional chiral HPLC analysis of amino acids and related compounds in a variety of real world samples","\u003Cp style=\"text-align:justify;\">Most of the amino acids have enantiomers (D and L forms) due to the chiral center at the α-position. Although these D and L-enantiomers are formed in the racemic 50/50 mixtures by the chemical synthesis, L-enantiomers are predominant in living beings especially in higher animals like mammals. The antipodes (D-enantiomers) are believed to be not present in higher animals for a long time, however, several D-amino acids were found in various tissues and physiological fluids of mammals including humans along with the progress of analytical technologies.\u003C/p>","\u003Cp style=\"text-align:justify;\">Physiological functions and diagnostic values have also been reported for some of these D-amino acids, and their precise determination is highly expected for the screening of new bioactive substances and/or biomarkers. However, the amounts of D-amino acids in biological samples are trace in most cases, and the determination was disturbed by the presence of predominant L-amino acids and uncountable intrinsic substances like peptides. The similar situations are observed for the analysis of chiral amino acids in various real world samples including foods, beverages and also extraterrestrial matrices. Therefore, for the quantification of chiral amino acids, the analytical methods with high sensitivity, selectivity and wide enantioselectivity have to be developed and utilized. For this purpose, multidimensional LC methods integrating several separation modes are useful. In the present study, the amino acids were derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) to form chiral carboxylic acids. The NBD-derivatized amino acids could be determined with high sensitivity and also showed appropriate retention to the reversed-phase, anion-exchange and mixed-mode columns. In the first dimension of the multi-dimensional separation, reversedphase columns are normally used due to the high resolution and reproducibility. The target NBD-amino acid fractions are multiple heart-cut and automatically transferred to the next dimensions. Enantiomer separations were always performed in the last chromatographic dimension equipped with Pirkle-type chiral stationary phases. To have higher selectivity, an additional separation column could be inserted between the reversed-phase and enantioselective columns, and/or having mass spectrometer for the detection. Using these multi-dimensional LC systems, a variety of trace levels of D-amino acids were found in the brain tissues, peripheral tissues and physiological fluids of mammals. The amounts of specific D-forms were altered by the change of pathophysiological conditions including renal dysfunction and metabolic disorders. By the methods, various real world samples were analyzed, and relatively high levels of D-alanine, aspartic acid, glutamic acid and serine were observed in fermented foods/beverages. In the extraterrestrial samples, the presence of nonproteinogenic amino acid enantiomers were demonstrated. The multi-dimensional LC concept is also applicable to chiral hydroxy acids and peptides and further studies on their origins and physiological meanings are in progress.\u003C/p>","2026-02-03T14:23:46.468Z","2026-02-06T21:13:27.046Z","2026-02-03T14:23:48.435Z","145",[2370],{"id":200,"name":2371,"committee":16,"position":16,"affiliation":2372,"email":16,"biography":2373,"createdAt":2374,"updatedAt":2375,"url_path_id":2376,"contactPhoto":2377,"socialLinks":2409,"url_path":2410},"Kenji Hamase","Kyushu University, Japan","\u003Cp style=\"text-align:justify;\">He graduated from The University of Tokyo and obtained his Ph.D. degree in 1996.  Subsequently, he moved to Kyushu University, and was promoted to the full Professor in 2016 (Vice Dean for international affairs from 2018).  He is the Editor of the Journal of Pharmaceutical and Biomedical Analysis and Permanent International Committee members of HPLC and PBA conferences.  His current research interests focus on the development of multi-dimensional HPLC methods for chiral amino acids and related compounds to study on their physiological functions, diagnostic values and the design of functional foods.\u003C/p>","2025-11-07T17:29:37.695Z","2026-02-03T14:23:16.089Z","63",{"id":2378,"name":2379,"alternativeText":16,"caption":16,"width":2380,"height":2381,"formats":2382,"hash":2405,"ext":1294,"mime":1297,"size":2406,"url":2407,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2408,"updatedAt":2408},81,"77d407ed413d2310e6007297a12cf565-1.jpg",1521,1781,{"large":2383,"small":2389,"medium":2395,"thumbnail":2401},{"ext":1294,"url":2384,"hash":2385,"mime":1297,"name":2386,"path":16,"size":2387,"width":2388,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_77d407ed413d2310e6007297a12cf565_1_45106e7b0c.jpg","large_77d407ed413d2310e6007297a12cf565_1_45106e7b0c","large_77d407ed413d2310e6007297a12cf565-1.jpg",102.58,854,{"ext":1294,"url":2390,"hash":2391,"mime":1297,"name":2392,"path":16,"size":2393,"width":2394,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_77d407ed413d2310e6007297a12cf565_1_45106e7b0c.jpg","small_77d407ed413d2310e6007297a12cf565_1_45106e7b0c","small_77d407ed413d2310e6007297a12cf565-1.jpg",28.38,427,{"ext":1294,"url":2396,"hash":2397,"mime":1297,"name":2398,"path":16,"size":2399,"width":2400,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_77d407ed413d2310e6007297a12cf565_1_45106e7b0c.jpg","medium_77d407ed413d2310e6007297a12cf565_1_45106e7b0c","medium_77d407ed413d2310e6007297a12cf565-1.jpg",59.49,641,{"ext":1294,"url":2402,"hash":2403,"mime":1297,"name":2404,"path":16,"size":2208,"width":1213,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_77d407ed413d2310e6007297a12cf565_1_45106e7b0c.jpg","thumbnail_77d407ed413d2310e6007297a12cf565_1_45106e7b0c","thumbnail_77d407ed413d2310e6007297a12cf565-1.jpg","77d407ed413d2310e6007297a12cf565_1_45106e7b0c",291.7,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/77d407ed413d2310e6007297a12cf565_1_45106e7b0c.jpg","2025-11-07T17:29:31.372Z",[],"-36","-110",{"id":1507,"session":2413},{"id":1465,"title":2414,"teaser":2415,"body":90,"createdAt":2416,"updatedAt":2417,"publishedAt":2418,"url_path_id":2419,"contacts":2420,"url_path":2462},"New Approaches to Capillary LC Column Development","\u003Cp>As greener approaches to chemical analysis continue to grow in popularity, the significant decrease in mobile phase flow rates makes capillary LC an appealing choice for liquid chromatographic separations. In this presentation, recent advances in capillary LC column design will be described. The use of a “tube-in-manifold” design to enable circular cross-section columns within microfluidic column formats improves column loading and performance for integrated column chips. Integrated column cartridges where a column, heater, and detector are combined within a single unit promote ease-of-use for capillary LC, especially within miniaturized systems. Descriptions of various stationary phases used in these column formats will also be presented.\u003C/p>","2026-02-06T16:28:29.489Z","2026-02-06T16:28:32.027Z","2026-02-06T16:28:31.992Z","154",[2421],{"id":193,"name":2422,"committee":16,"position":16,"affiliation":2423,"email":16,"biography":2424,"createdAt":2425,"updatedAt":2426,"url_path_id":2427,"contactPhoto":2428,"socialLinks":2460,"url_path":2461},"Jim Grinias","Rowan University, Glassboro, New Jersey","\u003Cp style=\"text-align:justify;\">James Grinias is a Professor in the Department of Chemistry & Biochemistry at Rowan University in Glassboro, NJ. Dr. Grinias has a number of research interests focused on chemical separations and microfluidics, both at the fundamental level and for the analysis of biological systems.  He is the recipient of the 2021 American Chemical Society Satinder Ahuja Award for Young Investigators in Separation Science and the 2022 LCGC Emerging Leader in Chromatography. At Rowan, he teaches courses in general, analytical, and bioanalytical chemistry while also conducting research on UHPLC column performance and instrument miniaturization.\u003C/p>","2025-06-03T16:05:13.138Z","2026-01-07T19:56:08.362Z","39",{"id":1531,"name":2429,"alternativeText":16,"caption":16,"width":2430,"height":2431,"formats":2432,"hash":2456,"ext":1294,"mime":1297,"size":2457,"url":2458,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2459,"updatedAt":2459},"Grinias_2021Headshot_JPEG.jpg",1252,1520,{"large":2433,"small":2438,"medium":2444,"thumbnail":2450},{"ext":1294,"url":2434,"hash":2435,"mime":1297,"name":2436,"path":16,"size":1416,"width":2437,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Grinias_2021_Headshot_JPEG_5f7183660c.jpg","large_Grinias_2021_Headshot_JPEG_5f7183660c","large_Grinias_2021Headshot_JPEG.jpg",824,{"ext":1294,"url":2439,"hash":2440,"mime":1297,"name":2441,"path":16,"size":2442,"width":2443,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Grinias_2021_Headshot_JPEG_5f7183660c.jpg","small_Grinias_2021_Headshot_JPEG_5f7183660c","small_Grinias_2021Headshot_JPEG.jpg",32.22,412,{"ext":1294,"url":2445,"hash":2446,"mime":1297,"name":2447,"path":16,"size":2448,"width":2449,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Grinias_2021_Headshot_JPEG_5f7183660c.jpg","medium_Grinias_2021_Headshot_JPEG_5f7183660c","medium_Grinias_2021Headshot_JPEG.jpg",63.29,618,{"ext":1294,"url":2451,"hash":2452,"mime":1297,"name":2453,"path":16,"size":2454,"width":2455,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Grinias_2021_Headshot_JPEG_5f7183660c.jpg","thumbnail_Grinias_2021_Headshot_JPEG_5f7183660c","thumbnail_Grinias_2021Headshot_JPEG.jpg",4.98,128,"Grinias_2021_Headshot_JPEG_5f7183660c",212.52,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Grinias_2021_Headshot_JPEG_5f7183660c.jpg","2025-06-03T16:05:10.928Z",[],"-14","-118",{"id":150,"session":2464},{"id":1507,"title":2465,"teaser":2466,"body":2467,"createdAt":2468,"updatedAt":2469,"publishedAt":2470,"url_path_id":2471,"contacts":2472,"url_path":2510},"Multimodal Liquid Chromatography for Characterizing Advanced Drug Formulations","\u003Cp style=\"text-align:justify;\">Advanced drug formulations, such as polymer-encapsulated drugs for extended release or lipid nanoparticles for delivery of labile RNA treatments (RNA-LNP), require extensive characterization. A multimodal liquid chromatography system (multiLC) was designed for multiattribute characterization. The multiLC features an on-line trap column with a follow-on column to separate compounds not captured by the trap column. \u003C/p>","\u003Cp style=\"text-align:justify;\">Compounds captured by the trap column can then be back-eluted to another column for separation and determination. This setup can also use different or common detector systems for each separation line. A series of 6-port valves and multiple pumps allows for versatile on-line multimodal separations. MultiLC has been used to characterize the degradation of a polymer-encapsulated protein drug for ocular treatment. This embodiment featured the use of restricted access media to capture small molecules and exclude large molecules. Large molecules were directed to size exclusion chromatography and trapped small molecules were separated using reversed phase chromatography. UV/Vis and mass spectrometry detectors were used. In another embodiment, a polyethyleneimine-modified spongy monolith trap column was used to separate RNA-LNP formulations by ion exclusion chromatography. Different populations of RNA-LNP could be resolved and shown to contain different lipid compositions. This presentation will provide an overview of multiLC applications developed in our lab to date.\u003C/p>","2026-02-06T16:32:32.093Z","2026-02-06T16:32:34.096Z","2026-02-06T16:32:34.090Z","155",[2473],{"id":219,"name":2474,"committee":16,"position":16,"affiliation":2475,"email":16,"biography":2476,"createdAt":2477,"updatedAt":2478,"url_path_id":2479,"contactPhoto":2480,"socialLinks":2508,"url_path":2509},"Kevin Schug","University of Texas at Arlington","\u003Cp style=\"text-align:justify;\">Kevin A. Schug is Professor and the Shimadzu Distinguished Professor of Analytical Chemistry in the Department of Chemistry and Biochemistry at The University of Texas at Arlington (UTA).  He received his B.S. degree in Chemistry in 1998 from the College of William and Mary, and his Ph.D. degree in Chemistry from Virginia Tech in 2002 under the tutelage of Prof. Harold McNair.  From 2003-2005, he performed post-doctoral research at the University of Vienna in Austria with Prof. Dr. Wolfgang Lindner. Since joining UTA in 2005, his research has been focused on the theory and application of separation science and mass spectrometry for solving a variety of analytical and physical chemistry problems, in the fields of forensic, environmental, pharmaceutical, biological, and energy research.  He has over 220 peer-reviewed publications and over 700 presentations, posters, and invited talks to his group’s credit.  He has been the primary mentor and research advisor to more than 40 graduate and 80 undergraduate students.  Dr. Schug has received several research awards, including the 2009 Emerging Leader Award in Chromatography by LCGC Magazine and the 2013 American Chemical Society Division of Analytical Chemistry Young Investigator in Separation Science Award. He was named to the 2019, 2021, and 2023 The Analytical Scientist’s Top 100 Power Lists of the most influential analytical chemists in the world.  In 2024, he received the Silver Jubilee Medal from the Chromatographic Society (UK). For his teaching, he received the 2014 University of Texas System Regents’ Outstanding Teaching Award and in 2017, was awarded the J. Calvin Giddings Award for Excellence in Analytical Chemistry Education by the American Chemical Society. He is a Fellow of both the University of Texas System’s and U.T. Arlington’s Academy of Distinguished Teachers.  He is also a Fellow of U.T. Arlington’s Distinguished Service Leaders.\u003C/p>","2025-06-03T16:07:15.059Z","2025-07-15T17:33:24.901Z","41",{"id":2321,"name":2481,"alternativeText":16,"caption":16,"width":2482,"height":2482,"formats":2483,"hash":2504,"ext":1294,"mime":1297,"size":2505,"url":2506,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2507,"updatedAt":2507},"Kevin_Schug_cropped.jpg",2608,{"large":2484,"small":2489,"medium":2494,"thumbnail":2499},{"ext":1294,"url":2485,"hash":2486,"mime":1297,"name":2487,"path":16,"size":2488,"width":41,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Kevin_Schug_cropped_73ea6cb33c.jpg","large_Kevin_Schug_cropped_73ea6cb33c","large_Kevin_Schug_cropped.jpg",136.09,{"ext":1294,"url":2490,"hash":2491,"mime":1297,"name":2492,"path":16,"size":2493,"width":48,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Kevin_Schug_cropped_73ea6cb33c.jpg","small_Kevin_Schug_cropped_73ea6cb33c","small_Kevin_Schug_cropped.jpg",29.09,{"ext":1294,"url":2495,"hash":2496,"mime":1297,"name":2497,"path":16,"size":2498,"width":55,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Kevin_Schug_cropped_73ea6cb33c.jpg","medium_Kevin_Schug_cropped_73ea6cb33c","medium_Kevin_Schug_cropped.jpg",71.47,{"ext":1294,"url":2500,"hash":2501,"mime":1297,"name":2502,"path":16,"size":2503,"width":937,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Kevin_Schug_cropped_73ea6cb33c.jpg","thumbnail_Kevin_Schug_cropped_73ea6cb33c","thumbnail_Kevin_Schug_cropped.jpg",3.94,"Kevin_Schug_cropped_73ea6cb33c",810.25,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Kevin_Schug_cropped_73ea6cb33c.jpg","2025-07-11T22:06:48.035Z",[],"-16","-119",{"id":1589,"session":2512},{"id":150,"title":2513,"teaser":2514,"body":2515,"createdAt":2516,"updatedAt":2517,"publishedAt":2518,"url_path_id":2519,"contacts":2520,"url_path":2550},"Enabling New Insights into the Living Brain Metabolome Using LC-MS/MS and Untargeted Chemometrics","\u003Cp style=\"text-align:justify;\">Central to advancing neuroscience is characterizing and monitoring the chemical composition of the brain extracellular space. Neurotransmitters, neuromodulators, and other metabolites within this microenvironment reflect several physiological functions occurring simultaneously on different spatiotemporal scales. Elucidating the role that these metabolites play in normal and diseased brains can improve our understanding of neurological disorders, thereby providing potential new drug targets and therapies.\u003C/p>","\u003Cp style=\"text-align:justify;\">This presentation will demonstrate how analytical advances in liquid chromatography-tandem mass spectrometry and untargeted chemometrics can enable a deeper annotation of the living brain metabolome. Using in vivo microdialysis sampling, we can routinely monitor hundreds of compounds present in the brain metabolome. These compounds not only represent a wide range of chemical functionalities but also exhibit diverse biological functions. Leveraging this sampling framework, we define baseline and cocaine-induced differences in neurochemistry between two behavioral phenotypes in a rodent model of addiction. These differences were found to be associated with several metabolic pathways such as stress, neuroinflammation, energy usage, and neurotransmission. Ultimately, these findings broaden our understanding of addiction’s impact on the brain and serve as the basis for ongoing efforts to better characterize neurochemical adaptations. \u003C/p>","2026-02-06T16:43:31.948Z","2026-02-06T16:43:33.644Z","2026-02-06T16:43:33.637Z","156",[2521],{"id":2522,"name":2523,"committee":16,"position":16,"affiliation":2524,"email":16,"biography":2525,"createdAt":2526,"updatedAt":2526,"url_path_id":2527,"contactPhoto":2528,"socialLinks":2548,"url_path":2549},51,"Caitlin Cain","University of Michigan","\u003Cp style=\"text-align:justify;\">Caitlin Cain is a postdoctoral research fellow at the University of Michigan, supported by a National Institutes of Health Postdoctoral Individual National Research Service Award (F32 Fellowship). Previously, she earned her Ph.D. in Chemistry from the University of Washington in 2024 and B.S. degrees in Chemistry and Forensic Science from Virginia Commonwealth University in 2019. Her research specializes in the development of chemometric techniques to improve the untargeted analysis of chromatographic data. She has co-authored 23 journal publications, with 13 as first-author. Her research efforts have been recognized with several accolades, including a National Science Foundation (NSF) Graduate Research Fellowship, a Rising Star in Analytical Chemistry award at 2024 American Chemical Society (ACS) Fall Meeting, and the LCGC International Rising Stars of Separation Science Award. She also currently serves as Secretary for the ACS Subdivision on Chromatography and Separations Chemistry. \u003C/p>","2026-01-29T21:50:45.347Z","136",{"id":2529,"name":2530,"alternativeText":16,"caption":16,"width":2531,"height":2532,"formats":2533,"hash":2544,"ext":1294,"mime":1297,"size":2545,"url":2546,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2547,"updatedAt":2547},133,"Cain_headshot (1).jpg",448,540,{"small":2534,"thumbnail":2539},{"ext":1294,"url":2535,"hash":2536,"mime":1297,"name":2537,"path":16,"size":2538,"width":1732,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Cain_headshot_1_0fbe406e24.jpg","small_Cain_headshot_1_0fbe406e24","small_Cain_headshot (1).jpg",37.24,{"ext":1294,"url":2540,"hash":2541,"mime":1297,"name":2542,"path":16,"size":2543,"width":828,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Cain_headshot_1_0fbe406e24.jpg","thumbnail_Cain_headshot_1_0fbe406e24","thumbnail_Cain_headshot (1).jpg",5.37,"Cain_headshot_1_0fbe406e24",43.15,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Cain_headshot_1_0fbe406e24.jpg","2026-01-29T21:50:34.340Z",[],"-102","-120",{"id":813,"session":2552},{"id":2024,"title":2553,"teaser":2554,"body":2555,"createdAt":2556,"updatedAt":2557,"publishedAt":2558,"url_path_id":2559,"contacts":2560,"url_path":2594},"Chromatographic Approaches to Improving Identification and Estimation of Number of Compounds present in the Metabolome and Industrial Samples","\u003Cp style=\"text-align:justify;\">LC-MS methods have been critical for advancing metabolomics. A persistent finding has been that while many features, i.e. signals at a given m/z and retention time, are detected in complex samples using untargeted LC-MS, a relatively small number of metabolites are identified.\u003C/p>","\u003Cp style=\"text-align:justify;\">For example, it is not uncommon to detect over 104 features and identify only 200-500 compounds from MS/MS spectra. Further, often known significant compounds are not identified in the data sets. One reason for this is inability to acquire high quality MS/MS spectra. We have shown that combining several simple techniques like preconcentration, extended gradient times, iterative analysis, and multidimensional fractionation can dramatically increase the number of identified compounds. Using these approaches we identified over 2000 metabolites in plasma. A second issue that many features are degenerate, i.e. they are the sample compound detected as different isotopes, adducts, or in-source decay. We have developed a lack of fit metric, which fits chromatographic features at a given retention time to identify degeneracies. This method is based on the concept that the same compound will give the same chromatographic peak shape regardless of what species is detected in the mass spectrometer. Using this approach, we show dramatic reduction in the number of unknown (unannotated) features in biological samples. The same approach also reduced the number of unknowns in an analysis of contaminants in a polymer sample.\u003C/p>","2026-02-06T21:08:54.059Z","2026-02-06T21:08:56.478Z","2026-02-06T21:08:56.464Z","158",[2561],{"id":345,"name":2562,"committee":16,"position":16,"affiliation":2563,"email":16,"biography":90,"createdAt":2564,"updatedAt":2564,"url_path_id":2565,"contactPhoto":2566,"socialLinks":2592,"url_path":2593},"Robert T. Kennedy","University of Michigan, USA","2025-06-03T15:44:04.851Z","32",{"id":896,"name":2567,"alternativeText":16,"caption":16,"width":41,"height":2568,"formats":2569,"hash":2588,"ext":1294,"mime":1297,"size":2589,"url":2590,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2591,"updatedAt":2591},"large_Kennedy_Bob_cropped_1eabf4beae.jpg",899,{"small":2570,"medium":2576,"thumbnail":2582},{"ext":1294,"url":2571,"hash":2572,"mime":1297,"name":2573,"path":16,"size":2574,"width":48,"height":2575},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_large_Kennedy_Bob_cropped_1eabf4beae_da6b3daaaf.jpg","small_large_Kennedy_Bob_cropped_1eabf4beae_da6b3daaaf","small_large_Kennedy_Bob_cropped_1eabf4beae.jpg",27.43,450,{"ext":1294,"url":2577,"hash":2578,"mime":1297,"name":2579,"path":16,"size":2580,"width":55,"height":2581},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_large_Kennedy_Bob_cropped_1eabf4beae_da6b3daaaf.jpg","medium_large_Kennedy_Bob_cropped_1eabf4beae_da6b3daaaf","medium_large_Kennedy_Bob_cropped_1eabf4beae.jpg",56.07,674,{"ext":1294,"url":2583,"hash":2584,"mime":1297,"name":2585,"path":16,"size":2586,"width":2587,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_large_Kennedy_Bob_cropped_1eabf4beae_da6b3daaaf.jpg","thumbnail_large_Kennedy_Bob_cropped_1eabf4beae_da6b3daaaf","thumbnail_large_Kennedy_Bob_cropped_1eabf4beae.jpg",5.26,174,"large_Kennedy_Bob_cropped_1eabf4beae_da6b3daaaf",93.73,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Kennedy_Bob_cropped_1eabf4beae_da6b3daaaf.jpg","2025-06-03T15:44:01.879Z",[],"-7","-122",{"id":1531,"session":2596},{"id":813,"title":2597,"teaser":2598,"body":2599,"createdAt":2600,"updatedAt":2601,"publishedAt":2602,"url_path_id":2603,"contacts":2604,"url_path":2645},"Investigating mass transfer phenomena of oligonucleotides in liquid chromatography","\u003Cp style=\"text-align:justify;\">Oligonucleotides (ONs) are synthetic nucleic acid polymers that are transforming modern therapeutics by enabling sequence-specific recognition of nucleic acids, most commonly RNA, enabling modulation of gene and protein expression. An increasing number of ON-based drugs is currently in development to address diseases that were previously difficult or impossible to treat with conventional medicines based on small molecules. ON manufacturing typically generates numerous structurally related impurities that must be carefully monitored and controlled to ensure product quality and safety. High-Performance Liquid Chromatography (HPLC) remains the primary analytical technique for this purpose. Despite recent advances in column technology and stationary phases, HPLC analysis of ONs continues to be highly challenging due to the intrinsic complexity of these samples and the limited understanding of how specific column parameters influence ON separation.\u003C/p>","\u003Cp style=\"text-align:justify;\">This work represents a first step toward a systematic investigation of the key column parameters governing the efficiency of ON analysis. For this purpose, plate heights were determined for representative ONs using different column technologies, including monodisperse, fully porous and superficially porous particles, enabling the construction of van Deemter curves. To ensure an unbiased comparison of column performance, operating conditions were controlled to maintain constant pressure and retention factors across all measurements. Molecular diffusion coefficients were determined using the Taylor–Aris method, while effective diffusion coefficients were obtained via peak-parking experiments on a modified UHPLC instrument, providing insight into the longitudinal and intraparticle diffusion behavior of ONs. Specific challenges and unexpected observations associated with ONs, in contrast to smallmolecule analysis, will be discussed as well.\u003C/p>","2026-02-06T21:11:12.883Z","2026-02-06T21:11:14.817Z","2026-02-06T21:11:14.810Z","159",[2605],{"id":257,"name":2606,"committee":16,"position":16,"affiliation":2607,"email":16,"biography":2608,"createdAt":2609,"updatedAt":2610,"url_path_id":2611,"contactPhoto":2612,"socialLinks":2643,"url_path":2644},"Deirdre Cabooter","University of Leuven (KU Leuven), Belgium","\u003Cp style=\"text-align:justify;\">Deirdre Cabooter is currently a Full Professor at the Department of Pharmaceutical and Pharmacological Sciences at the University of Leuven (KU Leuven) in Belgium. She obtained a PhD in Chemical Engineering under supervision of Prof. Gert Desmet in 2009 and was appointed as a tenure-track research professor at KU Leuven in 2011. Her current research is directed towards a deeper understanding of mass transfer phenomena in liquid chromatography, the analysis of complex samples in pharmaceutical, bio-analytical, food and environmental applications using 1D-LC and 2D-LC, retention modeling, and solutions for automated method development based on machine learning. She has published more than 150 peer-reviewed papers and book chapters. She received the LCGC Emerging Leader in Chromatography Award in 2017, the Jubilee medal of the Chromatographic Society in 2020, the JFK Huber Lecture Award of the Austrian Society of Analytical Chemistry in 2023, and is an editor of Journal of Chromatography A since 2018.\u003C/p>","2025-06-03T16:06:35.269Z","2025-06-03T16:06:48.314Z","40",{"id":2613,"name":2614,"alternativeText":16,"caption":16,"width":2615,"height":2616,"formats":2617,"hash":2639,"ext":1294,"mime":1297,"size":2640,"url":2641,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2642,"updatedAt":2642},47,"Cabooter_HPLC2023.jpg",1148,765,{"large":2618,"small":2624,"medium":2629,"thumbnail":2634},{"ext":1294,"url":2619,"hash":2620,"mime":1297,"name":2621,"path":16,"size":2622,"width":41,"height":2623},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Cabooter_HPLC_2023_e0da691dba.jpg","large_Cabooter_HPLC_2023_e0da691dba","large_Cabooter_HPLC2023.jpg",46.46,666,{"ext":1294,"url":2625,"hash":2626,"mime":1297,"name":2627,"path":16,"size":2628,"width":48,"height":1637},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Cabooter_HPLC_2023_e0da691dba.jpg","small_Cabooter_HPLC_2023_e0da691dba","small_Cabooter_HPLC2023.jpg",14.79,{"ext":1294,"url":2630,"hash":2631,"mime":1297,"name":2632,"path":16,"size":2633,"width":55,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Cabooter_HPLC_2023_e0da691dba.jpg","medium_Cabooter_HPLC_2023_e0da691dba","medium_Cabooter_HPLC2023.jpg",28.93,{"ext":1294,"url":2635,"hash":2636,"mime":1297,"name":2637,"path":16,"size":2638,"width":1648,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Cabooter_HPLC_2023_e0da691dba.jpg","thumbnail_Cabooter_HPLC_2023_e0da691dba","thumbnail_Cabooter_HPLC2023.jpg",4.77,"Cabooter_HPLC_2023_e0da691dba",54.56,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Cabooter_HPLC_2023_e0da691dba.jpg","2025-06-03T16:06:46.050Z",[],"-15","-123",{"id":2647,"session":2648},48,{"id":1531,"title":2649,"teaser":2650,"body":2651,"createdAt":2652,"updatedAt":2653,"publishedAt":2654,"url_path_id":2655,"contacts":2656,"url_path":2683},"Retention Time - Aligned Method Development Through In Silico Chromatography Modeling","\u003Cp style=\"text-align:justify;\">New drug substances pose challenging demands on discovery and process chemistry which requires adequate and fast advancement in analytical tools to avoid bottlenecks in drug development. Challenges encountered in analyzing new medicines go beyond the complexities encountered during the manufacturing process, especially for biopharmaceuticals and multicombination drugs.\u003C/p>","\u003Cp style=\"text-align:justify;\">In this work, we highlight some of the novel analytical technologies and tools used in pharmaceutical laboratories for streamlining method development, which includes systematic exploration of chromatography columns and mobile phases to allow finding the right combination of column and mobile phase. This is followed by in silico simulation using a minimum number of experiments to predict optimum chromatographic conditions to maximum resolution between target peaks. In this work, we present a computer-assisted modeling approach that enables the development of retention time- In this work, we present a computer-assisted modeling approach that enables the development of retention-time–aligned chromatographic methods, facilitating robust and efficient method transfer across varying experimental conditions, chromatography systems, and laboratories.aligned chromatographic methods, facilitating robust and efficient method transfer across varying experimental conditions, chromatography systems, and laboratories.\u003C/p>","2026-02-06T21:34:44.067Z","2026-02-06T21:34:45.732Z","2026-02-06T21:34:45.726Z","160",[2657],{"id":270,"name":2658,"committee":16,"position":16,"affiliation":2659,"email":16,"biography":2660,"createdAt":2661,"updatedAt":2661,"url_path_id":2662,"contactPhoto":2663,"socialLinks":2681,"url_path":2682},"Imad Haidar Ahmad","Amgen","\u003Cp style=\"text-align:justify;\">Imad Haidar Ahmad is a Research Director in the Discovery Chemistry and Externalization department at Amgen, where he leads the Synthetic Separations team. His team plays a central role in enabling the purification and characterization of complex synthetic molecules that support Amgen’s drug discovery and development efforts.\u003C/p>\u003Cp style=\"text-align:justify;\">Imad earned his Ph.D. from Florida State University under the mentorship of Dr. André Striegel and completed his postdoctoral research with Professor Peter Carr at the University of Minnesota.\u003C/p>\u003Cp style=\"text-align:justify;\">Imad has extensive expertise in macromolecular characterization, method development, multiscale purifications, multidimensional liquid chromatography, and chromatography modeling. He is the author of over 60 publications and was the recipient of the Young Investigator Award from the Chinese American Chromatography Association in 2022.\u003C/p>\u003Cp style=\"text-align:justify;\">His work has been features on the front covers of LCGC, Analytical Chemistry, Green Chemistry, The Analyst, and Separation Science Plus, reflecting the broad impact of his contributions to analytical chemistry and chromatographic science.\u003Cbr> \u003C/p>","2025-07-17T22:56:05.563Z","46",{"id":2664,"name":2665,"alternativeText":16,"caption":16,"width":2666,"height":2666,"formats":2667,"hash":2677,"ext":1294,"mime":1297,"size":2678,"url":2679,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2680,"updatedAt":2680},60,"Imad Haidar Ahmad Picture.jpg",712,{"small":2668,"thumbnail":2672},{"ext":1294,"url":2669,"hash":2670,"mime":1297,"name":2671,"path":16,"size":963,"width":48,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Imad_Haidar_Ahmad_Picture_40dc3ba0a1.jpg","small_Imad_Haidar_Ahmad_Picture_40dc3ba0a1","small_Imad Haidar Ahmad Picture.jpg",{"ext":1294,"url":2673,"hash":2674,"mime":1297,"name":2675,"path":16,"size":2676,"width":937,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Imad_Haidar_Ahmad_Picture_40dc3ba0a1.jpg","thumbnail_Imad_Haidar_Ahmad_Picture_40dc3ba0a1","thumbnail_Imad Haidar Ahmad Picture.jpg",5.15,"Imad_Haidar_Ahmad_Picture_40dc3ba0a1",74.83,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Imad_Haidar_Ahmad_Picture_40dc3ba0a1.jpg","2025-07-17T22:55:04.065Z",[],"-20","-124",{"id":432,"session":2685},{"id":2613,"title":2686,"teaser":2687,"body":2688,"createdAt":2689,"updatedAt":2690,"publishedAt":2691,"url_path_id":2692,"contacts":2693,"url_path":2717},"High-Performance Affinity Chromatography","\u003Cp style=\"text-align:justify;\">The development of advanced biopolymer drugs necessitates the development of analytical tools with precise selectivity. Affinity liquid chromatography (aLC) is such technique, useful for specific isolation of target analytes from complex media. We describe development of high-performance aLC columns based on covalently immobilized ligands, or immobilization of biotinylated ligands on streptavidin modified sorbent. In the latter case the biotinylated affinity ligands were loaded on column and characterized in chromatographic experimental setup. Both proteins and nucleic acids were immobilized on the aLC sorbent and used as affinity selectors.\u003C/p>","\u003Cp style=\"text-align:justify;\">We describe applications of aLC for sensitive analysis of monoclonal antibodies (mAb), messenger RNA (mRNA) and other nucleic acids. The analysis can be performed with high speed and sensitivity using 20 x 2.1 mm column format packed with small nonporous particles. We demonstrate that aLC could be integrated with size-exclusion chromatography for advanced characterization of unbound and bound aLC fractions.\u003C/p>","2026-02-12T22:12:04.905Z","2026-02-12T22:12:07.425Z","2026-02-12T22:12:07.414Z","164",[2694],{"id":639,"name":2695,"committee":16,"position":16,"affiliation":1668,"email":16,"biography":2696,"createdAt":2697,"updatedAt":2698,"url_path_id":2699,"contactPhoto":2700,"socialLinks":2715,"url_path":2716},"Martin Gilar","\u003Cp style=\"text-align:justify;\">Dr. Martin Gilar (*1966) received his Ph.D. in analytical chemistry from Institute of Chemical Technology in Prague (1996). He spent postdoc years in Hybridon Inc. (1996-1998) and Northeastern University in Boston (1998) developing separation methods for antisense oligonucleotides and fraction collector for DNA molecules. Since 1998 he has worked at Waters Corp. in Milford, Massachusetts, participating in column, sample preparation and instrument research.\u003C/p>\u003Cp style=\"text-align:justify;\">Dr. Martin Gilar is a Scientific Fellow in the Separations R&D group at Waters Corporation. He has more than 30 years of experience in the separation sciences, including chromatography, electrophoresis, and mass spectrometry. His research interest is the analysis of biopolymers, peptides, and nucleic acids. He has published over 75 peer reviewed papers. Dr. Gilar is recipient of Jaroslav Janak 2022 medal and Chromatographic Society Jubilee medal in 2023.\u003C/p>","2026-02-12T22:11:08.753Z","2026-02-12T22:16:13.783Z","163",{"id":2701,"name":2702,"alternativeText":16,"caption":16,"width":2703,"height":48,"formats":2704,"hash":2711,"ext":1294,"mime":1297,"size":2712,"url":2713,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2714,"updatedAt":2714},148,"small_Gilar_Headshot_3_crop_74f8b85d06 (1).jpg",435,{"thumbnail":2705},{"ext":1294,"url":2706,"hash":2707,"mime":1297,"name":2708,"path":16,"size":2709,"width":2710,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_small_Gilar_Headshot_3_crop_74f8b85d06_1_2d3137f256.jpg","thumbnail_small_Gilar_Headshot_3_crop_74f8b85d06_1_2d3137f256","thumbnail_small_Gilar_Headshot_3_crop_74f8b85d06 (1).jpg",3.98,135,"small_Gilar_Headshot_3_crop_74f8b85d06_1_2d3137f256",26.13,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Gilar_Headshot_3_crop_74f8b85d06_1_2d3137f256.jpg","2026-02-12T22:16:12.088Z",[],"-127","-128",{"id":2228,"session":2719},{"id":2647,"title":2720,"teaser":2721,"body":2722,"createdAt":2723,"updatedAt":2724,"publishedAt":2725,"url_path_id":2726,"contacts":2727,"url_path":2767},"An Isobaric Tagging Strategy for Multiplexed Sequencing and Quantification of RNA Oligonucleotides by LC-MS/MS","\u003Cp style=\"text-align:justify;\">Chemical modifications of ribonucleic acid (RNA) are increasingly recognized to play central roles in therapeutic and endogenous RNAs. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the gold standard for directly detecting and sequencing massaltering RNA modifications with single-nucleotide resolution, but this powerful technique suffers from limited sample throughput and quantitative accuracy.\u003C/p>","\u003Cp style=\"text-align:justify;\">Isobaric tagging addresses these fundamental challenges by enabling sample multiplexing and highly accurate relative quantification. While isobaric tagging methods are routine in proteomics workflows, no analogous strategies are available for RNA oligonucleotides. This technical limitation precludes the development of high-throughput RNA sequencing and quantification by LC-MS/MS. Here, we describe the development of an isobaric tagging method specifically designed for RNA analysis by LC-MS/MS. Our approach provides a platform for multiplexed sequencing and relative quantification of RNA and its chemical modifications. In theory, our method allows up to 16 RNA samples to be analyzed simultaneously that display reporter ions distinguished by 1 Da. We apply our strategy for multiplexed LC-MS/MS sequencing and relative quantification of synthetic RNAs and endogenous transfer RNA-derived small RNAs (tsRNA) from an animal model.\u003C/p>","2026-02-12T22:14:35.118Z","2026-02-12T22:14:37.321Z","2026-02-12T22:14:37.306Z","165",[2728],{"id":2729,"name":2730,"committee":16,"position":16,"affiliation":2731,"email":16,"biography":2732,"createdAt":2733,"updatedAt":2734,"url_path_id":2735,"contactPhoto":2736,"socialLinks":2765,"url_path":2766},58,"Kevin Clark","Tufts University","\u003Cp style=\"text-align:justify;\">Kevin Clark is an Assistant Professor of Chemistry at Tufts University. He obtained a PhD in Analytical Chemistry from Iowa State University in 2018 and was then awarded a Beckman Institute Postdoctoral Fellowship at the University of Illinois Urbana-Champaign. At Tufts, Prof. Clark’s research program develops new approaches for sample preparation, separations, and mass spectrometry to measure RNA chemical modifications in biological systems. For this work, he was selected to the Beckman Young Investigator Award Program in 2024.\u003C/p>","2026-02-12T22:06:02.194Z","2026-02-12T22:06:12.096Z","162",{"id":740,"name":2737,"alternativeText":16,"caption":16,"width":1936,"height":2738,"formats":2739,"hash":2761,"ext":1294,"mime":1297,"size":2762,"url":2763,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2764,"updatedAt":2764},"Kevin Clark_headshot.jpg",1120,{"large":2740,"small":2745,"medium":2750,"thumbnail":2756},{"ext":1294,"url":2741,"hash":2742,"mime":1297,"name":2743,"path":16,"size":2744,"width":2244,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Kevin_Clark_headshot_cb82794ab6.jpg","large_Kevin_Clark_headshot_cb82794ab6","large_Kevin Clark_headshot.jpg",59.97,{"ext":1294,"url":2746,"hash":2747,"mime":1297,"name":2748,"path":16,"size":2749,"width":2250,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Kevin_Clark_headshot_cb82794ab6.jpg","small_Kevin_Clark_headshot_cb82794ab6","small_Kevin Clark_headshot.jpg",19.73,{"ext":1294,"url":2751,"hash":2752,"mime":1297,"name":2753,"path":16,"size":2754,"width":2755,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Kevin_Clark_headshot_cb82794ab6.jpg","medium_Kevin_Clark_headshot_cb82794ab6","medium_Kevin Clark_headshot.jpg",37.49,536,{"ext":1294,"url":2757,"hash":2758,"mime":1297,"name":2759,"path":16,"size":2760,"width":1433,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Kevin_Clark_headshot_cb82794ab6.jpg","thumbnail_Kevin_Clark_headshot_cb82794ab6","thumbnail_Kevin Clark_headshot.jpg",3.6,"Kevin_Clark_headshot_cb82794ab6",71.71,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Kevin_Clark_headshot_cb82794ab6.jpg","2026-02-12T22:05:42.426Z",[],"-126","-129",{"id":2522,"session":2769},{"id":432,"title":2770,"teaser":2771,"body":2772,"createdAt":2773,"updatedAt":2774,"publishedAt":2775,"url_path_id":2776,"contacts":2777,"url_path":2817},"New insights into red wine color evolution by LC×LC hyphenated to ion mobility spectrometry-HR-MS","\u003Cp style=\"text-align:justify;\">The color of young red wines is primarily determined by the anthocyanins extracted from black grape skins during maceration. Anthocyanins are however highly reactive, and from the moment they are extracted become involved in a range of reactions with a host of wine constituents to produce more stable anthocyanin-derived pigments. As a consequence, the levels of grapederived anthocyanins rapidly decrease during the first few years of ageing, and their contribution to the color of aged wines is limited and overshadowed by the derived pigments. Significant progress has been made in elucidating the reactions involved in the production of several derived pigment classes through model solution studies. A complete understanding of wine color evolution during ageing, however, remains elusive because of the challenges associated with analyzing the large number of derived pigments often present at low levels in the complex wine medium.\u003C/p>","\u003Cp style=\"text-align:justify;\">In this contribution, we report the development and optimization of an on-line comprehensive two-dimensional HILIC×RP-LC separation hyphenated to ion mobility spectrometry (IMS)-high resolution MS (HR-MS) as a suitable analytical method for the detailed investigation of the evolution of red wine pigments as a function of wine age. Two sets of single-vineyard wines of the same cultivar, spanning six consecutive vintages, were analyzed to shed light on the changes in their pigment composition. Optimal HILIC×RP-LC conditions accommodating the unique chromatographic behavior of anthocyanins were derived using an in-house automated method development and optimization program. The combination of highly efficient LC×LC separation and IMS-HR-MS detection enabled the tentative assignment of 196 pigmented molecules comprising several classes of anthocyanin derivatives in the studied wines. Among these, several new classes of derived pigments are reported in wine for the first time, and the reactions leading to their formation are proposed. Quantification of the main pigments in the studied wines was performed using HILIC×RP-LC-UV detection. To relate compositional measurements to chromatic impact, the contribution of each pigment class to color expression was estimated by calculating the effective flavylium cation concentration at wine pH. The data indicate a reduction in the contribution of grape-derived anthocyanins to wine color to less than 10%, with derivative classes like vitisins and pinotins largely responsible for color in 8-year-old wines. The findings demonstrate how optimized LC×LC-IMS-HR-MS analysis contributes new knowledge on the evolution of wine pigments.\u003C/p>","2026-02-13T18:31:37.183Z","2026-02-26T17:08:16.625Z","2026-02-13T18:31:39.465Z","167",[2778],{"id":2664,"name":2779,"committee":16,"position":16,"affiliation":2780,"email":16,"biography":2781,"createdAt":2782,"updatedAt":2782,"url_path_id":2783,"contactPhoto":2784,"socialLinks":2815,"url_path":2816},"André de Villiers","Stellenbosch University","\u003Cp style=\"text-align:justify;\">André de Villiers is a Professor in Analytical Chemistry at Stellenbosch University, South Africa. His research activities include fundamental studies and the practical application of chromatographic separations, with the emphasis on natural product analysis. Specific areas of interest include comprehensive 2-dimensional liquid- and gas chromatography, ion mobility spectrometry and advanced mass spectrometric methods in combination with separation methods. He is author or co-author of more than 100 scientific papers and the recipient of the 2009 Csaba Horváth Award and LCGC’s Emerging Leader in Chromatography Award in 2014.\u003C/p>","2026-02-13T18:30:59.707Z","166",{"id":766,"name":2785,"alternativeText":16,"caption":16,"width":2786,"height":2330,"formats":2787,"hash":2811,"ext":35,"mime":38,"size":2812,"url":2813,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2814,"updatedAt":2814},"AdeVilliers.png",1840,{"large":2788,"small":2794,"medium":2800,"thumbnail":2806},{"ext":35,"url":2789,"hash":2790,"mime":38,"name":2791,"path":16,"size":2792,"width":2793,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Ade_Villiers_8b39ddd8f9.png","large_Ade_Villiers_8b39ddd8f9","large_AdeVilliers.png",1288.79,613,{"ext":35,"url":2795,"hash":2796,"mime":38,"name":2797,"path":16,"size":2798,"width":2799,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Ade_Villiers_8b39ddd8f9.png","small_Ade_Villiers_8b39ddd8f9","small_AdeVilliers.png",330.15,307,{"ext":35,"url":2801,"hash":2802,"mime":38,"name":2803,"path":16,"size":2804,"width":2805,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Ade_Villiers_8b39ddd8f9.png","medium_Ade_Villiers_8b39ddd8f9","medium_AdeVilliers.png",726.95,460,{"ext":35,"url":2807,"hash":2808,"mime":38,"name":2809,"path":16,"size":2810,"width":1288,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Ade_Villiers_8b39ddd8f9.png","thumbnail_Ade_Villiers_8b39ddd8f9","thumbnail_AdeVilliers.png",38.48,"Ade_Villiers_8b39ddd8f9",2347.87,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Ade_Villiers_8b39ddd8f9.png","2026-02-13T18:30:31.230Z",[],"-130","-131",{"id":1769,"session":2819},{"id":2228,"title":2820,"teaser":2821,"body":2822,"createdAt":2823,"updatedAt":2824,"publishedAt":2825,"url_path_id":2826,"contacts":2827,"url_path":2865},"Impurity and diastereomer profiling of siRNA oligonucleotides using multiple modes and dimensions of separation","\u003Cp style=\"text-align:justify;\">Therapeutic oligonucleotides continue to offer hope for the treatment and prevention of uncurable diseases. High performance liquid chromatography is an essential tool for separating impurities and identifying quality attributes of these complex therapeutic modalities; however, current methodologies are insufficient for full characterization.\u003C/p>","\u003Cp style=\"text-align:justify;\">In this presentation, hydrophilic interaction (HILIC) and ion-pairing reversed phase (IPRP) liquid chromatography will be discussed in the context of separating therapeutic oligonucleotide impurities and diastereomers ranging in length from 20 to 40 nucleotides. HILIC offers unique selectivity for certain degradation products and offers improved peak shape for conjugated phosphorothioate oligonucleotides. Implementing HILIC as a denaturing method for siRNA duplexes remains a challenge due to the high on-column melting temperature of siRNA duplexes under these chromatographic conditions. IPRP separations of siRNA offer the highest resolving power and the broad ability to tailor the separation by changing ion pairing reagent and column temperature. Finally, two-dimensional separations will be presented as an avenue to enhance the resolving power of impurities and simultaneously separate siRNA duplex impurities and diastereomers in a single chromatographic analysis.\u003C/p>","2026-02-18T20:34:26.524Z","2026-02-18T20:34:29.221Z","2026-02-18T20:34:29.202Z","171",[2828],{"id":2829,"name":2830,"committee":16,"position":16,"affiliation":2831,"email":16,"biography":2832,"createdAt":2833,"updatedAt":2833,"url_path_id":2834,"contactPhoto":2835,"socialLinks":2863,"url_path":2864},61,"Matt Sorensen","Eli Lilly and Company","\u003Cp style=\"text-align:justify;\">Matt is a Research Scientist at Eli Lilly and Company in the Synthetic Molecule Design and Development department. He received his Ph.D. in Analytical Chemistry from the University of Michigan under Professor Robert Kennedy, focusing on capillary liquid chromatography-mass spectrometry instrumentation for metabolite and lipid separations. His current work focuses on developing 1D and 2D LC-MS methodologies for therapeutic peptides and oligonucleotides.  Matt is an author or co-author on 15 peer-reviewed publications and has given 13 scientific conference presentations. Outside of his technical contributions, Matt is a mentor and community volunteer both inside and outside of the laboratory.\u003C/p>","2026-02-18T20:30:37.514Z","170",{"id":2302,"name":2836,"alternativeText":16,"caption":16,"width":2837,"height":2837,"formats":2838,"hash":2859,"ext":1294,"mime":1297,"size":2860,"url":2861,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2862,"updatedAt":2862},"PD9_5353-Teams.jpg",1600,{"large":2839,"small":2844,"medium":2849,"thumbnail":2854},{"ext":1294,"url":2840,"hash":2841,"mime":1297,"name":2842,"path":16,"size":2843,"width":41,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_PD_9_5353_Teams_38d407203a.jpg","large_PD_9_5353_Teams_38d407203a","large_PD9_5353-Teams.jpg",84.3,{"ext":1294,"url":2845,"hash":2846,"mime":1297,"name":2847,"path":16,"size":2848,"width":48,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_PD_9_5353_Teams_38d407203a.jpg","small_PD_9_5353_Teams_38d407203a","small_PD9_5353-Teams.jpg",23.49,{"ext":1294,"url":2850,"hash":2851,"mime":1297,"name":2852,"path":16,"size":2853,"width":55,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_PD_9_5353_Teams_38d407203a.jpg","medium_PD_9_5353_Teams_38d407203a","medium_PD9_5353-Teams.jpg",48.67,{"ext":1294,"url":2855,"hash":2856,"mime":1297,"name":2857,"path":16,"size":2858,"width":937,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_PD_9_5353_Teams_38d407203a.jpg","thumbnail_PD_9_5353_Teams_38d407203a","thumbnail_PD9_5353-Teams.jpg",3.85,"PD_9_5353_Teams_38d407203a",198.69,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/PD_9_5353_Teams_38d407203a.jpg","2026-02-18T20:30:21.833Z",[],"-134","-135",{"id":2321,"session":2867},{"id":2522,"title":2868,"teaser":2869,"body":2870,"createdAt":2871,"updatedAt":2872,"publishedAt":2873,"url_path_id":2874,"contacts":2875,"url_path":2913},"Examining bias in sample preparation for proteomics experiments","\u003Cp style=\"text-align:justify;\">Proteomics experiments using liquid chromatography with tandem mass spectrometry (LCMS/MS) have become valuable for identifying changes in protein abundance and posttranslational modifications (PTMs) during disease progression. In these experiments, proteins are extracted from cells and/or tissues in the presence of chemical additives that maintain protein solubility. However, these additives can suppress protein digestion, negatively impact LC separations of peptides, and reduce peptide ionization.\u003C/p>","\u003Cp style=\"text-align:justify;\">Thus, after extraction, proteins undergo sample clean-up to remove problematic additives prior to LC-MS/MS. Furthermore, many peptides with PTMs are present at lower abundance than unmodified peptides, making their detection challenging due to ionization suppression. Enrichment methods can be used to improve detection of these peptides with PTMs. Here, we examine how sample clean-up methods and chromatographic enrichment techniques bias the detection of proteins with different properties and PTMs. Specifically, we will discuss how hydrophilicity and hydrophobicity affect protein capture in SP3 and SP4, respectively. In addition, we will explore differences in detecting methylated peptides when using strong cation exchange (SCX) compared to no-enrichment methods. This work highlights how separations in sample preparation can bias the peptides, proteins, and PTMs that are detected by LC-MS/MS, which are important considerations when designing experiments to detect proteins that are relevant to disease progression.\u003C/p>","2026-02-19T23:03:41.488Z","2026-02-26T17:06:34.141Z","2026-02-19T23:03:45.036Z","174",[2876],{"id":2877,"name":2878,"committee":16,"position":16,"affiliation":2879,"email":16,"biography":2880,"createdAt":2881,"updatedAt":2881,"url_path_id":2882,"contactPhoto":2883,"socialLinks":2911,"url_path":2912},62,"Elyssia Gallagher","Baylor University","\u003Cp style=\"text-align:justify;\">Elyssia S. Gallagher received a Ph.D. in analytical chemistry at the University of Arizona (Tucson, Arizona, USA). As a graduate student, she designed and developed analytical methods, including building instrumentation for capillary liquid chromatography and capillary zone electrophoresis to characterize a variety of biological analytes, such as small molecules, peptides, and proteins. As a post-doctoral research associate at the National Institute of Standards & Technology (Rockville, Maryland, USA), she utilized liquid chromatography-mass spectrometry to characterize proteins and protein complexes using hydrogen/deuterium exchange. In 2015, she started her independent career at Baylor University (Waco, Texas, USA) in the Department of Chemistry and Biochemistry. Dr. Gallagher’s lab focuses on the development and application of novel analytical tools and methodologies to characterize glycans and proteins. Specifically, her lab has developed methods using a combination of liquid chromatography and mass spectrometry to characterize the structures, dynamics, and binding interactions of these biomolecules.\u003C/p>","2026-02-19T23:02:26.657Z","173",{"id":1364,"name":2884,"alternativeText":16,"caption":16,"width":2885,"height":2886,"formats":2887,"hash":2907,"ext":1294,"mime":1297,"size":2908,"url":2909,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2910,"updatedAt":2910},"20200514_rr_7867.jpg",6720,4480,{"large":2888,"small":2893,"medium":2898,"thumbnail":2903},{"ext":1294,"url":2889,"hash":2890,"mime":1297,"name":2891,"path":16,"size":2892,"width":41,"height":1631},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_20200514_rr_7867_174e66f886.jpg","large_20200514_rr_7867_174e66f886","large_20200514_rr_7867.jpg",63.08,{"ext":1294,"url":2894,"hash":2895,"mime":1297,"name":2896,"path":16,"size":2897,"width":48,"height":1637},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_20200514_rr_7867_174e66f886.jpg","small_20200514_rr_7867_174e66f886","small_20200514_rr_7867.jpg",22.93,{"ext":1294,"url":2899,"hash":2900,"mime":1297,"name":2901,"path":16,"size":2902,"width":55,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_20200514_rr_7867_174e66f886.jpg","medium_20200514_rr_7867_174e66f886","medium_20200514_rr_7867.jpg",42.39,{"ext":1294,"url":2904,"hash":2905,"mime":1297,"name":2906,"path":16,"size":971,"width":1648,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_20200514_rr_7867_174e66f886.jpg","thumbnail_20200514_rr_7867_174e66f886","thumbnail_20200514_rr_7867.jpg","20200514_rr_7867_174e66f886",1141.66,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/20200514_rr_7867_174e66f886.jpg","2026-02-19T23:02:05.976Z",[],"-137","-138",{"id":2915,"session":2916},55,{"id":2321,"title":2917,"teaser":2918,"body":2919,"createdAt":2920,"updatedAt":2921,"publishedAt":2922,"url_path_id":2923,"contacts":2924,"url_path":2963},"From Experiments to Algorithms: AI‑Powered Digital Transformation of Chromatographic Method Development","\u003Cp style=\"text-align:justify;\">Liquid chromatography underpins pharmaceutical development from early discovery through commercial manufacturing; however, chromatographic method development remains largely empirical, resource-intensive, and fragmented across development stages and scales. Advances in machine learning (ML) and in-silico modeling offer a unique opportunity to transform chromatographic method development into a more robust, scalable, and lifecycle-aware process suitable for industrial and regulated environments.\u003C/p>","\u003Cp style=\"text-align:justify;\">This talk will highlight a paradigm shift toward AI-enabled, end-to-end digital chromatographic method development, through industrial case studies spanning analytical and purification scales across multiple stages of chromatographic method development. By integrating physicochemical understanding with modern machine-learning approaches, Bayesian optimization, and predictive analytics, chromatographic workflows can transition from sequential experimentation to data-driven, decision-focused digital workflows that support method robustness, transferability, and long-term performance. Across method screening, optimization, and lifecycle monitoring, these integrated models function as a digital twin of the LC system, learning from historical and real-time data to guide experimental and operational decisions. Ultimately, this approach reframes chromatographic method development as a continuous, learning lifecycle, bridging experimentation, computation, and industrial execution to deliver more reliable, scalable, and future-ready LC workflows.\u003C/p>","2026-02-26T17:04:21.362Z","2026-02-26T17:04:24.737Z","2026-02-26T17:04:24.728Z","179",[2925],{"id":2926,"name":2927,"committee":16,"position":16,"affiliation":2928,"email":16,"biography":2929,"createdAt":2930,"updatedAt":2930,"url_path_id":2931,"contactPhoto":2932,"socialLinks":2961,"url_path":2962},64,"Pankaj Aggarwal","Merck","\u003Cp style=\"text-align:justify;\">Pankaj Aggarwal, Ph.D. is a Principal Scientist driving the evolution of chromatographic method development toward predictive, in-silico-first paradigms for pharmaceutical analysis. His work reimagines how analytical methods are designed, shifting from empirical trial-and-error to model-enabled, data-driven decision making. He leads multidisciplinary teams advancing GMP-validated digital platforms that embed analytics, modeling, and experimentation at scale, enabling faster, more robust development in regulated environments. Previously, Dr. Aggarwal helped pioneer the practical application of in-silico chromatography and advanced analytics to modernize analytical workflows. He has authored over 20 peer-reviewed publications, contributes to pre-competitive industry collaborations, and serves on the board of the Eastern Analytical Symposium. \u003C/p>","2026-02-26T17:00:14.478Z","178",{"id":2933,"name":2934,"alternativeText":16,"caption":16,"width":2935,"height":2935,"formats":2936,"hash":2957,"ext":1294,"mime":1297,"size":2958,"url":2959,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2960,"updatedAt":2960},160,"Pankaj_Aggarwal_Head_Shot.jpg",1683,{"large":2937,"small":2942,"medium":2947,"thumbnail":2952},{"ext":1294,"url":2938,"hash":2939,"mime":1297,"name":2940,"path":16,"size":2941,"width":41,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Pankaj_Aggarwal_Head_Shot_7b37a4e694.jpg","large_Pankaj_Aggarwal_Head_Shot_7b37a4e694","large_Pankaj_Aggarwal_Head_Shot.jpg",106.72,{"ext":1294,"url":2943,"hash":2944,"mime":1297,"name":2945,"path":16,"size":2946,"width":48,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Pankaj_Aggarwal_Head_Shot_7b37a4e694.jpg","small_Pankaj_Aggarwal_Head_Shot_7b37a4e694","small_Pankaj_Aggarwal_Head_Shot.jpg",35.17,{"ext":1294,"url":2948,"hash":2949,"mime":1297,"name":2950,"path":16,"size":2951,"width":55,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Pankaj_Aggarwal_Head_Shot_7b37a4e694.jpg","medium_Pankaj_Aggarwal_Head_Shot_7b37a4e694","medium_Pankaj_Aggarwal_Head_Shot.jpg",66.17,{"ext":1294,"url":2953,"hash":2954,"mime":1297,"name":2955,"path":16,"size":2956,"width":937,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Pankaj_Aggarwal_Head_Shot_7b37a4e694.jpg","thumbnail_Pankaj_Aggarwal_Head_Shot_7b37a4e694","thumbnail_Pankaj_Aggarwal_Head_Shot.jpg",6.13,"Pankaj_Aggarwal_Head_Shot_7b37a4e694",241.35,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Pankaj_Aggarwal_Head_Shot_7b37a4e694.jpg","2026-02-26T16:59:52.375Z",[],"-142","-143",{"id":2877,"session":2965},{"id":2664,"title":2966,"teaser":2967,"body":2968,"createdAt":2969,"updatedAt":2970,"publishedAt":2971,"url_path_id":2972,"contacts":2973,"url_path":2993},"Advancing ADCs with HIC and HIC-MS: from real-time bioconjugation monitoring to multi-attribute characterization","\u003Cp style=\"text-align:justify;\">Antibody drug conjugates (ADCs) represent one of the fastest-growing therapeutic modalities, yet their analytical characterization and process control remain fundamentally constrained by limitations in chromatographic–mass spectrometric integration. Hydrophobic interaction chromatography (HIC), the gold standard for drug-to-antibody ratio (DAR) analysis, has historically been incompatible with MS due to nonvolatile salts, while process monitoring tools lack the speed and dimensionality needed for modern ADC manufacturing.\u003C/p>","\u003Cp style=\"text-align:justify;\">Here, we present a next-generation process analytical technology (PAT) platform that transforms HIC into a real-time, multi-attribute monitoring tool for ADC bioconjugation. Central to this advance is the use of ammonium tartrate as a pseudo-volatile HIC salt, enabling both high-resolution separation and seamless compatibility with native mass spectrometry (MS). This innovation supports a unified workflow bridging process monitoring and molecular-level characterization.\u003C/p>\u003Cp style=\"text-align:justify;\">We developed a rapid multi-attribute HIC method capable of simultaneously tracking drug-to-antibody ratio (DAR), drug load distribution (DLD), and drug-linker (DL) concentration directly in complex reaction matrices. This approach enables continuous, high-frequency sampling of bioconjugation reactions, revealing kinetic behaviors inaccessible to traditional methods. Notably, we identified drug-linker dissolution as a rate-limiting step in slurry-based conjugation, providing actionable insight for process optimization. Guided by this data, reaction times were reduced by up to 90% while maintaining target DAR and minimizing over conjugation.\u003C/p>\u003Cp style=\"text-align:justify;\">In parallel, integration with a simplified online native HIC–MS workflow enables direct structural confirmation of DAR species without added complexity or loss of sensitivity.\u003C/p>\u003Cp style=\"text-align:justify;\">This work redefines HIC from a static analytical assay into a dynamic, MS-enabled PAT platform, delivering real-time process understanding and control. The approach establishes a scalable foundation for data-driven ADC manufacturing, accelerating development timelines while improving product quality and robustness.\u003C/p>","2026-03-13T20:12:12.967Z","2026-03-23T13:19:14.254Z","2026-03-13T20:12:15.586Z","195",[2974],{"id":382,"name":2975,"committee":16,"position":16,"affiliation":2976,"email":16,"biography":90,"createdAt":2977,"updatedAt":2977,"url_path_id":2978,"contactPhoto":2979,"socialLinks":2991,"url_path":2992},"Kelly Zhang","Genentech, Inc., USA","2025-06-03T16:04:32.487Z","38",{"id":813,"name":2980,"alternativeText":16,"caption":16,"width":48,"height":48,"formats":2981,"hash":2987,"ext":1294,"mime":1297,"size":2988,"url":2989,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":2990,"updatedAt":2990},"small_scientist_profile_kelly_zhang_500x500_27987693a2.jpg",{"thumbnail":2982},{"ext":1294,"url":2983,"hash":2984,"mime":1297,"name":2985,"path":16,"size":2986,"width":937,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_small_scientist_profile_kelly_zhang_500x500_27987693a2_26dfa39e11.jpg","thumbnail_small_scientist_profile_kelly_zhang_500x500_27987693a2_26dfa39e11","thumbnail_small_scientist_profile_kelly_zhang_500x500_27987693a2.jpg",5.31,"small_scientist_profile_kelly_zhang_500x500_27987693a2_26dfa39e11",33.16,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_scientist_profile_kelly_zhang_500x500_27987693a2_26dfa39e11.jpg","2025-06-03T16:04:30.592Z",[],"-13","-156",{"id":668,"session":2995},{"id":2829,"title":2996,"teaser":2997,"body":2998,"createdAt":2999,"updatedAt":3000,"publishedAt":3001,"url_path_id":3002,"contacts":3003,"url_path":3045},"Introducing the Next-Generation Vacuum Ultraviolet (VUV) Universal Detector for Liquid Chromatography","\u003Cp style=\"text-align:justify;\">In drug development, precise characterization of material composition and purity is essential. Conventional liquid chromatography (LC) detectors like UV/vis (200–800 nm) spectrophotometers are limited in scope, as they cannot detect analytes lacking chromophores. Alternative detection methods—including refractive index, charged aerosol, light-scattering, and mass spectrometry—address some gaps, but each has distinct limitations.\u003C/p>","\u003Cp style=\"text-align:justify;\">Notably, all molecules exhibit strong absorption in the vacuum ultraviolet (VUV) region, providing a universal detection mechanism. Through the Enabling Technology Consortium (ETC), a new VUV universal detector has been developed and evaluated for pharmaceutical analysis. This presentation outlines the principles of VUV detection, showcases real-world applications, and summarizes performance from deployment in 11 global pharmaceutical labs using replicate prototypes. Results from interlaboratory comparisons reveal instrument and site consistency, while an in-depth discussion addresses key determinants of sensitivity, such as mobile phase selection. Together, these insights demonstrate the transformative potential of VUV detection in expanding analytical capabilities for drug development.\u003C/p>","2026-03-13T20:19:42.705Z","2026-03-31T23:36:43.403Z","2026-03-13T20:19:45.240Z","196",[3004],{"id":312,"name":3005,"committee":16,"position":16,"affiliation":3006,"email":16,"biography":3007,"createdAt":3008,"updatedAt":3008,"url_path_id":3009,"contactPhoto":3010,"socialLinks":3043,"url_path":3044},"Zachary Breitbach","Abbvie","\u003Cp style=\"text-align:justify;\">Zachary Breitbach obtained his BS in chemistry from Clarke College in 2005 and his PhD in analytical chemistry from UT Arlington in 2010. He co-founded AZYP, LLC dealing with new chemical separation media focused on chiral and HILIC separations. In 2016, he transitioned to AbbVie, developing new technologies and methods to support drug development. He has published over 70 peer-reviewed research articles, has been cited over 3000 times, and holds 3 patents related to the development of materials for chemical separations.\u003C/p>\u003Cp style=\"text-align:justify;\">Dr. Breitbach’s notable research contributions include the development of cyclofructan based chiral and HILIC phases and the development of superficially porous particle-based chiral stationary phases. He serves on the editorial board of LCGC N. America, J. Liq. Chromatogr. Relat. Technol., Separation Science Plus, and Chirality. He is the 2017 ACS Satinder Ahuja Awardee for Young Investigators in Separation Science and was named LCGC’s 2018 Emerging Leader Award in Chromatography. He has been listed twice (2018 and 2020) in the Analytical Scientist’s Top 40 Under 40 Power List. In 2022, he Chaired the International Chirality Conference. Most recently, he was named a recipient of the 2025 ACS Early Career Investigator Award.\u003C/p>","2025-08-11T17:16:35.969Z","53",{"id":3011,"name":3012,"alternativeText":16,"caption":16,"width":3013,"height":3014,"formats":3015,"hash":3039,"ext":1294,"mime":1297,"size":3040,"url":3041,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":3042,"updatedAt":3042},66,"ZSB Headshot EC1A5996-rotate&crop.jpg",2969,3089,{"large":3016,"small":3022,"medium":3028,"thumbnail":3034},{"ext":1294,"url":3017,"hash":3018,"mime":1297,"name":3019,"path":16,"size":3020,"width":3021,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523.jpg","large_ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523","large_ZSB Headshot EC1A5996-rotate&crop.jpg",120.05,961,{"ext":1294,"url":3023,"hash":3024,"mime":1297,"name":3025,"path":16,"size":3026,"width":3027,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523.jpg","small_ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523","small_ZSB Headshot EC1A5996-rotate&crop.jpg",27.98,481,{"ext":1294,"url":3029,"hash":3030,"mime":1297,"name":3031,"path":16,"size":3032,"width":3033,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523.jpg","medium_ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523","medium_ZSB Headshot EC1A5996-rotate&crop.jpg",65.21,721,{"ext":1294,"url":3035,"hash":3036,"mime":1297,"name":3037,"path":16,"size":3038,"width":1300,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523.jpg","thumbnail_ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523","thumbnail_ZSB Headshot EC1A5996-rotate&crop.jpg",3.38,"ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523",1027.09,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/ZSB_Headshot_EC_1_A5996_rotate_and_crop_ce5dee7523.jpg","2025-08-11T17:16:32.916Z",[],"-26","-157",{"id":2926,"session":3047},{"id":2877,"title":3048,"teaser":3049,"body":3050,"createdAt":3051,"updatedAt":3052,"publishedAt":3053,"url_path_id":3054,"contacts":3055,"url_path":3097},"Revisiting peak capacity production at ultra-short analysis time as a lever to improve the peak capacity of 2D-LC separations","\u003Cp style=\"text-align:justify;\">Over the past two-and-a-half decades numerous strides have been made in both the theory and practice of multi-dimensional liquid phase separations. Theoretical frameworks have been developed that enable the analyst to effectively manage compromises that must be made between analysis time, peak capacity, and analyte dilution. Very powerful and robust commercial instrumentation has been introduced that enables a wider range of users to effectively deploy the technology on a routine basis for analysis of both complex and difficult-to-resolve samples in fields ranging from polymer characterization to analysis of foods and beverages. Through this lens, we see that the evolution of multi-dimensional liquid chromatography during this century has been very impressive.\u003C/p>","\u003Cp style=\"text-align:justify;\">However, in spite of these advances, and theoretical predictions that suggest 2D separations should be superior to 1D ones for analyses longer than about 5 minutes, in practice most comprehensive 2D-LC separations are still more than 1 hour long. In this presentation we will discuss our recent efforts to fill this gap between 5 minutes and 1 hour by re-visiting the performance of ultra-fast second dimension separations that are needed in this space. Under conditions where first dimension peaks are severely undersampled, theory predicts that 2D-LC peak capacity is directly proportional to the productivity of the second dimension separation – i.e., peak capacity per unit of cycle time ( 2 tg/ 2nc). Currently we are leveraging a confluence of improvements in instrument and column technology to re-assess the productivity of second dimension separations in the range of 3 to 30 seconds. We will show that highly productive separations can be obtained at times much shorter than 20 seconds, where the previous optima were observed by Carr and coworkers, and discuss how these new capabilities could be leveraged in the context of actual 2D-LC separations.\u003C/p>","2026-03-13T20:20:13.988Z","2026-03-19T18:52:02.194Z","2026-03-13T20:20:16.172Z","197",[3056],{"id":288,"name":3057,"committee":16,"position":16,"affiliation":3058,"email":16,"biography":3059,"createdAt":3060,"updatedAt":3061,"url_path_id":3062,"contactPhoto":3063,"socialLinks":3095,"url_path":3096}," Dwight Stoll","Gustavus Adolphus College, Minnesota","\u003Cp style=\"text-align:justify;\">Dwight Stoll is Professor and Co-Chair of Chemistry at Gustavus Adolphus College in St. Peter, MN. He has authored or co-authored more than 100 peer-reviewed publications and five book chapters in separation science, speaks internationally on the topic, and is co-editor of the recent book: Multi-Dimensional Liquid Chromatography: Principles, practice, and applications. He has also written the monthly “LC Troubleshooting” column for LCGC Magazine since 2017, and co-hosts the Analytically Speaking podcast with Prof. Jim Grinias. His primary research focus is on the development of two-dimensional liquid chromatography (2D-LC) for both targeted and untargeted analyses. Within this area he has made contributions on many aspects of the technique including stationary phase characterization, biopharmaceutical analysis, new 2D-LC methodologies and instrumentation, and fundamental aspects including re-equilibration in gradient elution liquid chromatography and analyte focusing. He has taught several short courses on 2D-LC in recent years at venues including Pittcon and the international HPLC20XX series, and hosts multi-day hands-on trainings for multi-dimensional chromatography in his laboratory at Gustavus.\u003C/p>","2025-07-16T13:04:13.862Z","2025-12-29T16:01:40.836Z","45",{"id":639,"name":3064,"alternativeText":16,"caption":16,"width":3065,"height":3066,"formats":3067,"hash":3091,"ext":1294,"mime":1297,"size":3092,"url":3093,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":3094,"updatedAt":3094},"dsclip.jpg",1452,1661,{"large":3068,"small":3074,"medium":3079,"thumbnail":3085},{"ext":1294,"url":3069,"hash":3070,"mime":1297,"name":3071,"path":16,"size":3072,"width":3073,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_dsclip_88d17f240c.jpg","large_dsclip_88d17f240c","large_dsclip.jpg",96.21,874,{"ext":1294,"url":3075,"hash":3076,"mime":1297,"name":3077,"path":16,"size":3078,"width":42,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_dsclip_88d17f240c.jpg","small_dsclip_88d17f240c","small_dsclip.jpg",33.41,{"ext":1294,"url":3080,"hash":3081,"mime":1297,"name":3082,"path":16,"size":3083,"width":3084,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_dsclip_88d17f240c.jpg","medium_dsclip_88d17f240c","medium_dsclip.jpg",60.89,656,{"ext":1294,"url":3086,"hash":3087,"mime":1297,"name":3088,"path":16,"size":3089,"width":3090,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_dsclip_88d17f240c.jpg","thumbnail_dsclip_88d17f240c","thumbnail_dsclip.jpg",5.9,136,"dsclip_88d17f240c",219.68,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/dsclip_88d17f240c.jpg","2025-07-16T13:03:20.830Z",[],"-19","-158",{"id":757,"session":3099},{"id":668,"title":3100,"teaser":3101,"body":3102,"createdAt":3103,"updatedAt":3104,"publishedAt":3105,"url_path_id":3106,"contacts":3107,"url_path":3146},"Role of Specialized Extraction Techniques in Enhancing Liquid-Phase Separations of Complex Samples","\u003Cp style=\"text-align:justify;\">The analysis of complex environmental and biological matrices remains one of the principal challenges in liquid-phase separation science, where matrix interferences can significantly compromise chromatographic performance, column stability, and mass spectrometric detection. In many conventional workflows, insufficient sample cleanup leads to the introduction of co-extracted matrix components that contribute to column fouling, reduced separation efficiency, and ionization suppression in electrospray ionization (ESI).\u003C/p>","\u003Cp style=\"text-align:justify;\">This presentation will discuss the role of solid-phase microextraction (SPME), as an integrated sample preparation approach capable of significantly improving the robustness of liquid-phase analytical workflows. SPME employs selective sorbent coatings that enable simultaneous extraction and cleanup, allowing the enrichment of target analytes while minimizing the co-extraction of interfering matrix components. In particular, the use of biocompatible SPME coatings enables direct interfacing with complex matrices such as biological fluids and environmental samples, reducing sample manipulation and preventing the introduction of macromolecules and other fouling species into the chromatographic system. \u003C/p>\u003Cp style=\"text-align:justify;\">By selectively isolating analytes while excluding high-molecular-weight and strongly matrixassociated components, SPME contributes to improved chromatographic performance, enhanced column lifetime, and more stable electrospray ionization conditions. These benefits translate into improved separation efficiency, enhanced method robustness, and more reliable quantitative analysis when coupled with high-performance liquid chromatography (HPLC) and mass spectrometric detection. \u003C/p>\u003Cp style=\"text-align:justify;\">The presentation will highlight recent advances in SPME materials and configurations, and will illustrate how specialized extraction strategies can play a critical role in enabling reliable liquid-phase separations for highly complex samples.\u003C/p>","2026-03-13T20:22:46.535Z","2026-03-19T18:49:29.618Z","2026-03-13T20:22:49.502Z","198",[3108],{"id":276,"name":3109,"committee":16,"position":16,"affiliation":3110,"email":16,"biography":3111,"createdAt":3112,"updatedAt":3113,"url_path_id":3114,"contactPhoto":3115,"socialLinks":3144,"url_path":3145},"Emanuela Gionfriddo","University at Buffalo","\u003Cp style=\"text-align:justify;\">Emanuela Gionfriddo is an Associate Professor in the Department of Chemistry at the University at Buffalo, The State University of New York. Her research is centered on the development of advanced analytical separation techniques for complex biological and environmental samples, with a strong emphasis on green extraction methodologies and sustainable analytical chemistry. Dr. Gionfriddo earned her Ph.D. in Analytical Chemistry from the University of Calabria (Italy) in 2013 and subsequently joined the group of Prof. Janusz Pawliszyn at the University of Waterloo (Canada) as a Postdoctoral Fellow and manager of the Gas Chromatography section in the Industrially Focused Analytical Research Laboratory (InFAReL). Her work has been recognized with the 2024 Chinese American Chromatography Association Young Investigator Award, 2023 LCGC Emerging Leader in Chromatography Award, 2023 Eastern Analytical Symposium Young Investigator Award, and the 2022 ACS Analytical Division Satinder Ahuja Award for Young Investigators in Separation Science. Dr. Gionfriddo currently serves as Chair of the ACS Analytical Chemistry Subdivision on Chromatography and Separation Chemistry and associate editor for Journal of Separation Science and Separation Science Plus (Wiley).\u003C/p>","2025-07-15T16:28:22.415Z","2025-12-29T16:06:06.828Z","44",{"id":2729,"name":3116,"alternativeText":16,"caption":16,"width":3117,"height":3118,"formats":3119,"hash":3140,"ext":1294,"mime":1297,"size":3141,"url":3142,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":3143,"updatedAt":3143},"233A2432.jpg",3600,2401,{"large":3120,"small":3125,"medium":3130,"thumbnail":3135},{"ext":1294,"url":3121,"hash":3122,"mime":1297,"name":3123,"path":16,"size":3124,"width":41,"height":1631},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_233_A2432_e7a5539d10.jpg","large_233_A2432_e7a5539d10","large_233A2432.jpg",48.3,{"ext":1294,"url":3126,"hash":3127,"mime":1297,"name":3128,"path":16,"size":3129,"width":48,"height":1637},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_233_A2432_e7a5539d10.jpg","small_233_A2432_e7a5539d10","small_233A2432.jpg",15.47,{"ext":1294,"url":3131,"hash":3132,"mime":1297,"name":3133,"path":16,"size":3134,"width":55,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_233_A2432_e7a5539d10.jpg","medium_233_A2432_e7a5539d10","medium_233A2432.jpg",29.84,{"ext":1294,"url":3136,"hash":3137,"mime":1297,"name":3138,"path":16,"size":3139,"width":1648,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_233_A2432_e7a5539d10.jpg","thumbnail_233_A2432_e7a5539d10","thumbnail_233A2432.jpg",5.28,"233_A2432_e7a5539d10",528.18,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/233_A2432_e7a5539d10.jpg","2025-07-15T16:27:54.139Z",[],"-18","-159",{"id":3011,"session":3148},{"id":325,"title":3149,"teaser":3150,"body":3151,"createdAt":3152,"updatedAt":3153,"publishedAt":3154,"url_path_id":3155,"contacts":3156,"url_path":3183},"Using the Right Tool for the Job: A Selectivity-Driven View of Alternative Bonded Phases and HILIC","\u003Cp style=\"text-align:justify;\">Conventional C18 reversed-phase columns remain the default choice for many HPLC separations, yet their widespread use can obscure opportunities for improved performance through alternative selectivity. This work examines retention mechanisms associated with nontraditional stationary phases, with particular emphasis on embedded polar group and fluorinated reversed-phase materials. In addition, the use of hydrophilic interaction liquid chromatography (HILIC) for alternative selectivity is explored. By dissecting the molecular interactions governing retention and selectivity, this contribution highlights how changes in stationary-phase chemistry can produce substantial gains in resolution, robustness, and method simplicity. \u003Cbr> \u003C/p>","\u003Cp style=\"text-align:justify;\">A central theme is the emphasis on selectivity over efficiency in modern method development. While high efficiency can often be engineered through column dimensions and particle architecture, selectivity is dictated by the stationary phase chemistry. Deliberate exploitation of selectivity frequently enables faster analyses, reduced solvent consumption, and simplified sample preparation, aligning method development with green analytical chemistry principles.\u003C/p>\u003Cp style=\"text-align:justify;\">Several case studies are presented in which challenging separations were solved by moving beyond conventional C18 phases. Examples include the successful use of alternative reversedphase columns to resolve closely related analytes and the strategic application of HILIC to access orthogonal retention space. Collectively, these studies demonstrate that thoughtful selection of stationary phase chemistry—using the right tool for the job—can transform method development from an exercise in optimization to one of informed design. \u003C/p>","2026-01-26T15:30:34.822Z","2026-02-06T16:50:28.239Z","2026-01-26T15:30:37.153Z","131",[3157],{"id":2647,"name":3158,"committee":16,"position":16,"affiliation":3159,"email":16,"biography":3160,"createdAt":3161,"updatedAt":3161,"url_path_id":3162,"contactPhoto":3163,"socialLinks":3181,"url_path":3182},"David S. Bell ","Phiex Technologies & ASKkPrime, LLC","\u003Cp style=\"text-align:justify;\">Dr. David S. Bell is a seasoned chromatographer with more than 30 years of experience advancing separation science through research, product development, and mentorship. He is Director of Applied R&D at Phiex Technologies and founder of ASKkPrime, LLC, where he supports the development and commercialization of innovative technologies. His career includes senior leadership roles at Restek Corporation and MilliporeSigma, following a decade in pharmaceutical analytical development. An active voice in the field, he is a regular columnist for and serves on the editorial board of LCGC International, has authored over 95 publications, and presents globally in support of the chromatography community.\u003C/p>","2026-01-26T15:30:00.621Z","130",{"id":1689,"name":3164,"alternativeText":16,"caption":16,"width":1478,"height":55,"formats":3165,"hash":3177,"ext":35,"mime":38,"size":3178,"url":3179,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":3180,"updatedAt":3180},"pic_dave_7 (1).png",{"small":3166,"thumbnail":3172},{"ext":35,"url":3167,"hash":3168,"mime":38,"name":3169,"path":16,"size":3170,"width":3171,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_pic_dave_7_1_ec1e1bac1c.png","small_pic_dave_7_1_ec1e1bac1c","small_pic_dave_7 (1).png",440.71,416,{"ext":35,"url":3173,"hash":3174,"mime":38,"name":3175,"path":16,"size":3176,"width":1689,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_pic_dave_7_1_ec1e1bac1c.png","thumbnail_pic_dave_7_1_ec1e1bac1c","thumbnail_pic_dave_7 (1).png",47.61,"pic_dave_7_1_ec1e1bac1c",243.28,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/pic_dave_7_1_ec1e1bac1c.png","2026-01-26T15:29:57.714Z",[],"-96","-97",{"id":1220,"session":3185},{"id":601,"title":3186,"teaser":3187,"body":3188,"createdAt":3189,"updatedAt":3190,"publishedAt":3191,"url_path_id":3192,"contacts":3193,"url_path":3231},"Trapping-Enrichment Multidimensional LC Strategies for Challenging Biotherapeutic Targets","\u003Cp style=\"text-align:justify;\">Biotherapeutics such as monoclonal antibodies and antibody–drug conjugates (ADCs) play a vital role in modern medicine by providing highly targeted treatments for complex diseases. Isolating and characterizing product variants, degradation products, and other trace impurities within complex matrices, such as cell‑culture harvests or formulated drug products, is essential for ensuring biotherapeutic efficacy and safety. However, low‑level species present in biotherapeutics remain difficult to isolate due to challenges in sensitivity, recovery, and sample stability. We previously demonstrated an automated trapping‑enrichment multidimensional liquid chromatography (TE‑mDLC) strategy to isolate, enrich, and collect small‑molecule targets for detailed characterization.\u003C/p>","\u003Cp style=\"text-align:justify;\">This workflow integrates a high‑resolution first‑dimension separation, automated peak trapping, enrichment with buffer exchange, and a second‑dimension cleanup. In the present work, we extend the TE-mDLC workflow to enable biotherapeutic target isolation. We have established fundamental aspects, including proper combinations of column chemistries, dimensions, and flow rates, recovery optimization, and considerations for maintaining sample stability. We demonstrate the utility of this workflow with the isolation of low-level targets in the HILIC separation of an ADC. Attemptsto scale up to semi-preparative HILIC resulted in lower resolution, reduced recovery, and sample degradation during fraction collection and sample concentration. In contrast, the TE-mDLC workflow enabled isolation and enrichment of low-level targets for mass spectrometry characterization without extensive manual handling. Targets were stable over five days of TE cycles. The eluent was either directly hyphenated with a mass spectrometer or collected for offline characterization, where the final elution solvent could be supplemented with additives such as EDTA and methionine to prevent sample oxidation prior to characterization. In addition to addressing challenges with HILIC-based isolation, we also leverage native modes of separation to generate material suitable for biological activity assays and other studies where maintaining native conformation is critical. Taken together, this work establishes TE‑mDLC as a customizable platform for isolation and characterization of low‑level, unstable biotherapeutic targets when conventional preparative‑scale purification approaches are impractical.\u003C/p>","2026-02-03T14:11:29.393Z","2026-03-09T15:39:55.607Z","2026-02-03T14:11:31.849Z","143",[3194],{"id":3195,"name":3196,"committee":16,"position":16,"affiliation":2928,"email":16,"biography":3197,"createdAt":3198,"updatedAt":3198,"url_path_id":3199,"contactPhoto":3200,"socialLinks":3229,"url_path":3230},54,"Devin Makey","\u003Cp style=\"text-align:justify;\">Devin Makey earned his Ph.D. in Chemistry from the University of Michigan in 2025. Supported by a U.S. National Science Foundation Research Fellowship, his doctoral research focused on high‑throughput analytical methods for small‑molecule and protein pharmaceuticals. He is currently a Senior Scientist in the Advanced Method Solutions team within Analytical Research & Development at Merck, where he develops analytical strategies to enable vaccine, biotherapeutic, and small molecule pharmaceutical development. He is the recipient of the 2024 Csaba Horváth Young Scientist Award.\u003C/p>","2026-02-03T14:10:25.773Z","142",{"id":684,"name":3201,"alternativeText":16,"caption":16,"width":3202,"height":3202,"formats":3203,"hash":3225,"ext":3205,"mime":1297,"size":3226,"url":3227,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":3228,"updatedAt":3228},"Makey_Devin.JPG",2506,{"large":3204,"small":3210,"medium":3215,"thumbnail":3220},{"ext":3205,"url":3206,"hash":3207,"mime":1297,"name":3208,"path":16,"size":3209,"width":41,"height":41},".JPG","https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Makey_Devin_d3821c0665.JPG","large_Makey_Devin_d3821c0665","large_Makey_Devin.JPG",83.75,{"ext":3205,"url":3211,"hash":3212,"mime":1297,"name":3213,"path":16,"size":3214,"width":48,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Makey_Devin_d3821c0665.JPG","small_Makey_Devin_d3821c0665","small_Makey_Devin.JPG",24.4,{"ext":3205,"url":3216,"hash":3217,"mime":1297,"name":3218,"path":16,"size":3219,"width":55,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Makey_Devin_d3821c0665.JPG","medium_Makey_Devin_d3821c0665","medium_Makey_Devin.JPG",48.85,{"ext":3205,"url":3221,"hash":3222,"mime":1297,"name":3223,"path":16,"size":3224,"width":937,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Makey_Devin_d3821c0665.JPG","thumbnail_Makey_Devin_d3821c0665","thumbnail_Makey_Devin.JPG",4.08,"Makey_Devin_d3821c0665",390.65,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Makey_Devin_d3821c0665.JPG","2026-02-03T14:10:11.943Z",[],"-108","-109",{"id":696,"session":3233},{"id":757,"title":3234,"teaser":3235,"body":3236,"createdAt":3237,"updatedAt":3238,"publishedAt":3239,"url_path_id":3240,"contacts":3241,"url_path":3265},"Pete Carr: A pioneer in understanding the retention mechanism of reversed-phase liquid chromatography","\u003Cp style=\"text-align:justify;\">Peter Carr was a pioneer in separation science, specifically in liquid chromatography (LC), where he contributed so many pivotal insights. These include optimization theory, the use of the hydrophobic subtraction model, two-dimensional liquid chromatography (2DLC) and the thermodynamics of reversed phase liquid chromatography (RPLC), amongst other studies highlighting the most basic aspects of LC.\u003C/p>","\u003Cp style=\"text-align:justify;\">Pete and Ravinda Ranatunga (1) had done key experiments using hexadecane as an analog to the C18 stationary phase. Using headspace GC analysis, they were able to get accurate thermodynamics of small solutes in the solvent and in the hexadecane phase and showed the essential lipophilic driving force in RPLC. This was in contrast to the predominating solvophobic model of RPLC, devised by Horvath and coworkers (2). Pete labeled his work as “revisionary” (1). \u003C/p>\u003Cp style=\"text-align:justify;\">One of the many things Pete did was to bring my future coworker, Ilja Siepmann, and I together. Ilja was hired as an assistant professor at U. Minnesota and Pete realized that Ilja’s simulation methods, which were well-suited to phase equilibria problems, could be extremely complimentary to my molecular modeling work on RPLC. Shortly after my U Minnesota seminar, Ilja and I wrote an NSF grant as co-PI’s to investigate RPLC using Ilja’s configurational-bias Monte Carlo method in the Gibbs Ensemble (CBMC-GE). Using this methodology, we calculated the distribution of model solutes between a stationary phase consisting of C18 chains bound to silica in solvent systems of water/methanol and water/acetonitrile. In addition, we simulated the hexadecane experiment and showed excellent agreement with the Carr group results (1). This agreement gave us confidence we were producing high quality simulations with equilibrium results. The molecular dynamics technique, to this day, produces results only up to a few microseconds; far short of equilibrium conditions.\u003C/p>\u003Cp style=\"text-align:justify;\">Ilja and I have continued this research producing over 30 papers on the fundamental science of LC over the last 30 years and with 6 NSF-funded grants to expand this work into HILIC, mixedmode, polar embedded groups, supercritical fluid chromatography, and with a variety of solutes. \u003C/p>\u003Cp style=\"text-align:justify;\">In my talk I will highlight Pete’s experimental study and the connection to our simulation work. It is my honor to pay tribute to Pete’s work with this talk. Time permitting, I will also discuss Pete’s unique approach to fishing.\u003C/p>\u003Cp style=\"text-align:justify;\"> 1) A study of the enthalpy and entropy contributions of the stationary phase in reversed-phase liquid chromatography, R. P. J. Ranatunga, P. W. Carr Anal. Chem. 2000, 72, 5679-. \u003C/p>\u003Cp style=\"text-align:justify;\">2) Solvophobic interactions in liquid chromatography with nonpolar stationary phases, C. Horvath, W. Melander, I. Molnar J. Chromatogr. 125 (1976) 129-.\u003C/p>","2026-03-16T21:54:35.209Z","2026-03-16T22:05:51.730Z","2026-03-16T21:54:37.579Z","201",[3242],{"id":1220,"name":3243,"committee":16,"position":16,"affiliation":3244,"email":16,"biography":3245,"createdAt":3246,"updatedAt":3246,"url_path_id":3247,"contactPhoto":3248,"socialLinks":3263,"url_path":3264},"Mark Schure","Kroungold Analytical","\u003Cp style=\"text-align:justify;\">\u003Cspan style=\"background-color:oklch(100);color:oklch(0.200);\">Mark Schure has worked in separation science for over 40 years in industry and academics. He is presently the Chief Technology Officer at Kroungold Analytical, a consulting firm he started in 2012. Dr. Schure is Adjunct Professor in the department of Chemical and Biomolecular Engineering at the University of Delaware; a position he has had for over 30 years and adjunct professor of chemistry at Drexel University. He has published over 120 papers, 4 patents and edited the book “Multidimensional Liquid Chromatography.” His scientific interests include the fundamental separation science of complex molecules, polymers and colloids, colloid chemistry, computational materials science and all aspects of solving large-scale chemical and physical problems with computers. He has received numerous awards including the Dal Nogare award, the Uwe D. Neue award and the Eastern Analytical Symposium award in separation science.\u003C/span>\u003C/p>","2026-03-16T21:52:11.952Z","200",{"id":3249,"name":3250,"alternativeText":16,"caption":16,"width":48,"height":3251,"formats":3252,"hash":3259,"ext":1294,"mime":1297,"size":3260,"url":3261,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":3262,"updatedAt":3262},176,"small_Mark_Schure_63546a687d.jpg",472,{"thumbnail":3253},{"ext":1294,"url":3254,"hash":3255,"mime":1297,"name":3256,"path":16,"size":3257,"width":3258,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_small_Mark_Schure_63546a687d_330becf9d4.jpg","thumbnail_small_Mark_Schure_63546a687d_330becf9d4","thumbnail_small_Mark_Schure_63546a687d.jpg",3.95,165,"small_Mark_Schure_63546a687d_330becf9d4",20.72,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Mark_Schure_63546a687d_330becf9d4.jpg","2026-03-16T21:51:50.369Z",[],"-160","-161",{"id":3267,"session":3268},69,{"id":3011,"title":3269,"teaser":3270,"body":90,"createdAt":3271,"updatedAt":3272,"publishedAt":3273,"url_path_id":3274,"contacts":3275,"url_path":3300},"Analysis of Reversed Phase Liquid Chromatography Selectivity Data in the Spirit of the Hydrophobic Subtraction Model: A Tribute to Peter W. Carr","\u003Cp style=\"text-align:justify;\">Despite the popularity of reversed phase liquid chromatographic separations to address a wide range of analytical problems, there has yet to be a comprehensive model developed for the accurate prediction of separation selectivity over a broad range of potential analytes and chromatographic conditions. However, significant steps towards a comprehensive model have been the development of linear solvation energy relationships and the hydrophobic subtraction model (HSM), pioneered by Pete Carr.\u003C/p>","2026-03-16T22:04:29.022Z","2026-03-25T18:33:22.400Z","2026-03-16T22:04:31.562Z","203",[3276],{"id":696,"name":3277,"committee":16,"position":16,"affiliation":3278,"email":16,"biography":3279,"createdAt":3280,"updatedAt":3281,"url_path_id":3282,"contactPhoto":3283,"socialLinks":3298,"url_path":3299},"Sarah Rutan","Virginia Commonwealth University, USA","\u003Cp style=\"text-align:justify;\">Sarah C. Rutan is retired from Virginia Commonwealth University (VCU), in Richmond, VA, where she was on the faculty for 34 years.  She received her B.S. degree from Bates College in Lewiston, ME, and her M.S. and Ph.D. degrees from Washington State University in Pullman, WA.  Her research is focused on the development of chemometric methods for improving chromatographic analyses. She has over 100 publications and numerous presentations on this topic.  She has taken several sabbaticals, including several months with Peter Carr at the University of Minnesota in 1988 and 2011, 6 months with D. L. Massart at the Vrije Universiteit Brussels in 1995, and 3 months with Onno de Noord at Shell International Chemicals in 1996.  She was awarded the VCU College of Humanities and Sciences (H&S) Distinguished Service Award for 2000 and the VCU H&S Scholarship Award for 2005.  She was the chair of the Chemometrics in Analytical Chemistry Conference in Richmond, VA in June 2014.\u003C/p>","2026-03-16T22:04:04.915Z","2026-03-18T22:04:02.513Z","202",{"id":3284,"name":3285,"alternativeText":16,"caption":16,"width":3286,"height":3287,"formats":3288,"hash":3294,"ext":1294,"mime":1297,"size":3295,"url":3296,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":3297,"updatedAt":3297},179,"Sarah Rutan headshot.jpg",346,359,{"thumbnail":3289},{"ext":1294,"url":3290,"hash":3291,"mime":1297,"name":3292,"path":16,"size":3293,"width":1300,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Sarah_Rutan_headshot_258c02708c.jpg","thumbnail_Sarah_Rutan_headshot_258c02708c","thumbnail_Sarah Rutan headshot.jpg",3.87,"Sarah_Rutan_headshot_258c02708c",16.08,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Sarah_Rutan_headshot_258c02708c.jpg","2026-03-18T22:03:23.605Z",[],"-162","-163",{"id":789,"session":3302},{"id":1220,"title":3303,"teaser":3304,"body":3305,"createdAt":3306,"updatedAt":3307,"publishedAt":3308,"url_path_id":3309,"contacts":3310,"url_path":3352},"Chromatography Mass Spectrometry for the identification of new pollutants","\u003Cp style=\"text-align:justify;\">Comprehensive characterization of organic pollutants in real-world samples remains challenging due to matrix complexity, chemical diversity, and the prevalence of isomers. Efficient chromatographic separation is therefore critical for reliable analysis of emerging contaminants in complex environmental and biological matrices. This presentation addresses these needs through (i) chromatography–mass spectrometry workflows that enhance chemical coverage and identification confidence, and (ii) automation-oriented chromatographic platforms that translate high-selectivity separations into scalable practice.\u003C/p>","\u003Cp style=\"text-align:justify;\">Across GC–MS and LC–MS, chromatographic selectivity is leveraged to suppress interferences, expand coverage for compounds spanning a wide range of polarity and volatility, and—critically—resolve isomers and closely related components that cannot be distinguished by mass accuracy alone. Where one-dimensional separation is insufficient, multidimensional (e.g., two-dimensional) chromatography can provide additional resolving power for complex mixtures. Together, these strategies improve interpretability for both targeted quantification and discovery-oriented screening in matrices such as atmospheric fine particulate matter, human biosamples, and other environmental samples.\u003C/p>\u003Cp style=\"text-align:justify;\">The presentation further introduces automated chromatographic workflows that integrate sample extraction, cleanup, concentration, chromatographic separation (and optional fractionation), instrumental analysis, and toxicity/bioactivity evaluation when relevant. The overall goal is higher throughput and reproducibility while preserving chromatography-driven confidence in identification. Collectively, these advances demonstrate how separation science enables broader chemical surveillance, clearer mixture deconvolution, and practical high-throughput monitoring of emerging contaminants.\u003C/p>","2026-03-24T18:06:13.020Z","2026-03-24T18:06:16.759Z","2026-03-24T18:06:16.748Z","209",[3311],{"id":3267,"name":3312,"committee":16,"position":16,"affiliation":3313,"email":16,"biography":3314,"createdAt":3315,"updatedAt":3316,"url_path_id":3317,"contactPhoto":3318,"socialLinks":3350,"url_path":3351},"Guibin Jiang","Chinese Academy of Sciences, China","\u003Cp style=\"text-align:justify;\">Professor Jiang Guibin is now a full professor in the State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. His research is mainly focused on analytical development, environmental fate, toxicology and health effects of persistent organic pollutants, endocrine disruptors, organometallic compounds, nano-materials and new pollutants. He has contributed more than 1700 papers in peer-reviewed international scientific journals, and 27 monographs. He was elected to the member of Chinese Academy of Sciences in 2009, the fellow of the World Academy of Sciences (TWAS) in 2012，the fellow of the Royal Society of Chemistry (FRSC) in 2014 and the Member of the National Academy of Engineering (NAE, USA) in 2026. He has long served as the associate editor of ES&T (2006-2025) and is also the founding editors of NanoImpact, Eco-Environment and Health, and Environment and Health.\u003C/p>","2026-03-24T18:05:26.133Z","2026-03-25T13:45:46.164Z","208",{"id":576,"name":3319,"alternativeText":16,"caption":16,"width":3320,"height":3321,"formats":3322,"hash":3346,"ext":1294,"mime":1297,"size":3347,"url":3348,"previewUrl":16,"provider":24,"provider_metadata":16,"createdAt":3349,"updatedAt":3349},"Jiang Guibin2026.jpg",3098,3880,{"large":3323,"small":3329,"medium":3335,"thumbnail":3341},{"ext":1294,"url":3324,"hash":3325,"mime":1297,"name":3326,"path":16,"size":3327,"width":3328,"height":41},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/large_Jiang_Guibin2026_03b32f9fde.jpg","large_Jiang_Guibin2026_03b32f9fde","large_Jiang Guibin2026.jpg",58.53,798,{"ext":1294,"url":3330,"hash":3331,"mime":1297,"name":3332,"path":16,"size":3333,"width":3334,"height":48},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/small_Jiang_Guibin2026_03b32f9fde.jpg","small_Jiang_Guibin2026_03b32f9fde","small_Jiang Guibin2026.jpg",16.13,399,{"ext":1294,"url":3336,"hash":3337,"mime":1297,"name":3338,"path":16,"size":3339,"width":3340,"height":55},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/medium_Jiang_Guibin2026_03b32f9fde.jpg","medium_Jiang_Guibin2026_03b32f9fde","medium_Jiang Guibin2026.jpg",32.3,598,{"ext":1294,"url":3342,"hash":3343,"mime":1297,"name":3344,"path":16,"size":3345,"width":2080,"height":937},"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/thumbnail_Jiang_Guibin2026_03b32f9fde.jpg","thumbnail_Jiang_Guibin2026_03b32f9fde","thumbnail_Jiang Guibin2026.jpg",3.2,"Jiang_Guibin2026_03b32f9fde",909.67,"https://confcats-siteplex.s3.us-east-1.amazonaws.com/hplc26/Jiang_Guibin2026_03b32f9fde.jpg","2026-03-25T13:45:42.717Z",[],"-166","-167",{"data":3354,"meta":3355},{"id":251,"heading":289,"createdAt":294,"updatedAt":295,"publishedAt":296,"url_path_id":297,"url_path":290,"contentType":120},{},1792782831815]