Plenary Speakers | HPLC 2026 | Indianapolis, Indiana, USA

- HPLC 2027 Austria Program Chair
Designing Application-Driven MS Metabolomics at Scale
Mass spectrometry (MS)–based metabolomics continues to contend with extreme chemical heterogeneity, broad dynamic concentration ranges, and strong matrix effects—conditions that make a single, universal workflow unlikely. This plenary will examine how modular, application-driven workflows can be assembled to balance coverage, quantitative performance, and robustness, and where the field might converge on best practices without sacrificing flexibility.
- University at Buffalo
Continued Tinkering with Silica for Stationary Phases in Liquid Phase Separations
Silica particles are the predominant packing material used to assemble the stationary phase for liquid phase separations. Our research group has focused on investigating new strategies to develop silica-based chromatographic media that has resulted in the synthesis of organo-silicas in various formats, as well as unconventional methods to modify silica particles.
- The Ohio State University, USA
Separation Science and Mass Spectrometry Using Unique Carbon Materials
Carbon media are currently used for both selective and nonselective extraction as well as numerous chromatographic applications. Not surprisingly, carbon media have found applications in mass spectrometry as well.
- Kyoto University, Japan
High throughput proteomics with capillary-flow LC/MS/MS and StageTips
LC/MS/MS-based proteome sequencers have advanced rapidly but still do not fully meet the expectations of the research community. We focused on measurement speed and investigated various approaches to complete peptide sequencing by LC/MS/MS in approximately one minute. As a result, we developed a method to acquire 1,000 samples per day (1,000 SPD) in dataindependent acquisition mode by combining tandem MS with ion mobility separation, an online nano-LC column, and gradient elution in less than one minute at capillary-LC flow rates.
- University of Texas at Arlington
Characterization of Biological and Pharmacological Peptide Epimers and Their Post Transitional Modification: Combing LC, MS and Enzymatic Methods
The occurrence and roles of pepetide/protein epimers may vary substantially with progression from microbiotic to evermore advanced macrobiotic systems. We now understand some of the biosynthetic and regulatory pathways. Given their rarity, identifying them in a complex biological matrix can be difficult. Further, they have the same exact mass as their all L-AA counterparts. The pharmacological importance of peptide epimers and research thereon is subsequently escalating. In the realm of post-translational modifications (PTMs) of peptide/proteins, epimerization is rarely considered.